sapropterin

	What is the most important information I should know about sapropterin?
	What is sapropterin?
	What should I discuss with my health care provider before taking sapropterin?
	How should I take sapropterin?
	What happens if I miss a dose?
	What happens if I overdose?
	What should I avoid while taking sapropterin?
	What are the possible side effects of sapropterin?
	What other drugs will affect sapropterin?
	Where can I get more information?
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Before using sapropterin, tell your doctor if you are allergic to any drugs, or if you have liver disease, a history of stomach ulcer or bleeding, or a seizure disorder.

Also tell your doctor about any medications you use, especially levodopa (Larodopa, Altamet, Parcopa, Sinemet), methotrexate (Rheumatrex, Trexall), or any medication to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra).

To be sure sapropterin is helping your condition, your blood will need to be tested on a regular basis. Do not miss any scheduled appointments.

Sapropterin is only part of a complete program of treatment that also includes a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you must avoid to help control your condition.

If sapropterin is not controlling your condition properly, you may have symptoms such as behavior changes, numbness or tingling, or problems with speech, vision, or balance. Call your doctor if you have any of these symptoms.

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using sapropterin.

Sapropterin is a synthetic form of a natural salt that contributes to the function of a certain enzyme in the body. In people with a condition called phenylketonuria (PKU), this enzyme is lacking or missing in the body. Without the enzyme, phenylalanine levels can become elevated and cause a variety of neurologic symptoms.

Sapropterin is used to help the body activate the enzyme needed to control blood levels of phenylalanine. This medication is used in people with PKU.

Sapropterin may also be used for other purposes not listed in this medication guide.

Before using sapropterin, tell your doctor if you are allergic to any drugs, or if you have:

• liver disease;
• a history of stomach ulcer or bleeding; or
• epilepsy or other seizure disorder.

If you have any of these conditions, you may not be able to take sapropterin, or you may need a dose adjustment or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether sapropterin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Sapropterin is usually given once daily. Follow your doctor's instructions.

Sapropterin works best if you take it with food.

Dissolve the tablet in 4 to 8 ounces of water or apple juice. It will take about 15 minutes for the tablet to dissolve. Stir this mixture and then drink all of it right away. To make sure you get the entire dose, add a little more water or juice to the same glass, swirl gently and drink right away.

The tablet may not completely dissolve and you may see small pieces in the liquid. These pieces are safe for you to swallow.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Do not miss any scheduled appointments.

Sapropterin can reduce your phenylalanine blood levels within 24 hours of when you take it. However, it may take up to 30 days of using this medicine before it reaches its fullest effect in your body. For best results, keep using the medication as directed.

Sapropterin is only part of a complete program of treatment that also includes a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you must avoid to help control your condition.

Store sapropterin at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

Do not take 2 doses on the same day.

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include headache and dizziness.

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using sapropterin.

If sapropterin is not controlling your condition properly, you may have symptoms such as behavior changes, numbness or tingling, or problems with speech, vision, or balance. Call your doctor right away if you have any of these symptoms.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of the serious side effects below:

• seizure (convulsions);
• chest pain or heavy feeling, pain spreading to the arm or shoulder, general ill feeling;
• easy bruising or bleeding;
• fever, chills, body aches, flu symptoms;
• swelling in your hands or feet;
• pain or burning when you urinate;
• weakness or fainting;
• black, bloody, or tarry stools; or
• coughing up blood or vomit that looks like coffee grounds.

Less serious side effects may include:

• nausea, vomiting, stomach pain, diarrhea;
• runny or stuffy nose, cough;
• headache, feeling agitated;
• dizziness; or
• joint pain.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

The following drugs can interact with sapropterin. Tell your doctor if you are using any of these:

• levodopa (Larodopa, Altamet, Parcopa, Sinemet);
• methotrexate (Rheumatrex, Trexall);
• sildenafil (Viagra);
• tadalafil (Cialis); or
• vardenafil (Levitra).

This list is not complete and there may be other drugs that can interact with sapropterin. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Your pharmacist can provide more information about sapropterin.