Information on the following diseases can be found in the Related Disorders section of this report:

• Dengue Fever
• Viral Encephalitis
• Malaria

The symptoms of Yellow Fever are the sudden onset of fever and chills along with headache, backache, generalized pain, nausea, vomiting, flushed face and infection of the inner eyelid. The fever usually disappears after three days, reappearing several days later with new symptoms of jaundice, bleeding gums, soft palate hemorrhages, and the vomiting of blood (black vomit). The patient may go into shock during this phase.

Yellow Fever may also appear in a mild form with symptoms resembling influenza, malaria, dengue fever or typhoid. In this case, the fever usually lasts less than one week.
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Yellow Fever is caused by a virus spread by the bite by an infected mosquito. Initially, a mosquito acquires the disease by ingesting the blood of an infected host. The mosquito then transmits the infection to its next bite victim.

Yellow Fever affects males and females equally. People living in semitropical or tropical climates are at risk unless they are vaccinated against this infection. People in southern areas of the United States, living near marshes and swamps may be at risk during the summer months. However, most cases of Yellow Fever occur in Africa and South America.
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Symptoms of the following disorders can be similar to those of Yellow Fever. Comparisons may be useful for a differential diagnosis:

Dengue Fever is a disease also transmitted by a mosquito bite and characterized by a skin rash and a high fever with severe pain in the head and muscles. There is a sudden onset of symptoms with pain also occuring in the lower back, legs and joints. (For more information on this disorder, choose "Dengue Fever" as your search term in the Rare Disease Database.)

Viral Encephalitis is a disease characterized by fever, headache, vomiting, rigidity of the neck, lethargy and convulsions. Generalized muscular weakness and paralysis may also occur.

Malaria is a communicable disorder also spread through the bite of a mosquito. Symptoms include chills and fever, although not every case follows the same pattern. Symptoms may begin a week after exposure to the mosquito or months later. (For more information of this disorder, choose "Malaria" as your search term in the Rare Disease Database.)

The treatment of Yellow Fever is symptomatic and supportive. Preventative measures consist of mosquito control and a vaccine that prevents development of the infection. Immunity from a vaccination usually develops after 10 days and lasts for more than 10 years. In some cases, side effects associated with vaccination may occur five to 10 days later. These side effects affect approximately 5 percent of individuals receiving immunization and may include headache, fever, and/or aching muscles.
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A pharmaceutical company known as Genelabs Technologies, Inc., is working on an RNA-binding drug program that has produced several compounds that potentially inhibit viral activity. It is hoped that this might lead to drug treatment options for RNA viruses including yellow fever, hepatitis C, Japanese Encephalitis, and Dengue fever. More research is necessary to develop and test such drugs for safety and long-term effectiveness.
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INTERNAL MEDICINE, 2nd Ed.: Jay H. Stein, ed.-in-chief; Little, Brown and Co., 1987. Pp. 1594-1599.

THE MERCK MANUAL, Volume 1, 14th Ed.: Robert Berkow, M.D. ed.-in chief; Merck, Sharp & Dohme Laboratories., 1982. Pp. 120.

JOURNAL ARTICLES
Fournier-Caruana J, et al., In vitro potency assay for yellow fever vaccines: comparison of three vero cell lines sources. Biologicals. 2000;28:33-40.

Perraut R, et al., Stability-related studies on 17D yellow fever vaccine. Microbes Infect. 2000;2:33-8.

Tomori O, Impact of yellow fever on the developing world. Adv Virus Res. 1999;53:5-34.

Monath TO, Yellow fever: a medically neglected disease. Report on a seminar. Rev Infect Dis. 1987;9:165-75.

de Souza Lopes O, et al., Studies on yellow fever vaccine. I. Quality control parameters. J Biol Stand. 1987;159:323-9.