National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Bowenoid Papulosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Related Disorders List
Information on the following diseases can be found in the Related Disorders section of this report:
- Bowen's Disease
- Lichen Planus
Bowenoid Papulosis is a rare, sexually transmitted disorder thought to be caused by human papillomavirus type 16. This disorder is characterized by lesions that are found on the genitals of males and females. The lesions are reddish brown or violet in color, small, solid, raised and sometimes velvety.
Bowenoid Papulosis is a rare sexually transmitted infection that is characterized by lesions that are typically found on the genitals. These lesions may last from two weeks to several years. Females may be affected inside the vagina, on the clitoris, groin folds, labia major, labia minor and/or anus. Males may be affected on the glans, shaft and/or foreskin of the penis as well as the anus. The lesions found in Bowenoid Papulosis are usually reddish brown or violet in color, small, solid, smooth, raised and velvety. The lesions on females are usually darker than the lesions on males.
Many patients with Bowenoid Papulosis often have other types of viral infections that precede this condition. Herpes simplex, human papallomavirus, viral warts, and HIV infection have been found in some patients with this disorder. When viewed under a microscope the Bowenoid Papulosis tissue structure looks like pre-invasive squamous-cell carcinoma (a form of cancer cells). In some cases Bowenoid Papulosis has become malignant.
Bowenoid Papulosis is a sexually transmitted disorder thought to be caused by human papillomavirus type 16. Other viruses as well as a suppressed immune system may also play a role in contracting Bowenoid Papulosis.
Bowenoid Papulosis affects sexually active males (average age, 30) and females (average age, 32) equally. However, in the literature, Bowenoid Papulosis patients range in age from 3 to 80. It has recently been appearing in increasing numbers worldwide.
Symptoms of the following disorders can be similar to those of Bowenoid Papulosis. Comparisons may be useful for a differential diagnosis:
Bowen's Disease is characterized by a precancerous, slow growing skin malignancy. The major symptom is a red-brown, scaly or crusted patch on the skin which resembles psoriasis or dermatitis. It may occur on any part of the skin or in the mucous membranes. (For more information on this disorder, choose "Bowen's Disease" as your search term in the Rare Disease Database.)
Condyloma is a common infectious venereal disease that is caused by the human papillomavirus (HPV) and usually transmitted by direct sexual contact. The warts found in this disorder are small, soft, moist, pink or red elevations on the skin or mucous membranes of the genitals, mouth, anus or rectum. Typically the warts form in clusters. (For more information on this disorder, choose "Condyloma" as your search term in the Rare Disease Database.)
Lichen Planus is a recurrent, itchy, inflammatory eruption of the skin which is characterized by small, separate, angular spots that may grow together forming rough scaly patches. It is often accompanied by oral lesions. Women are most commonly affected by this disorder. The lesions are most commonly found on the joint surfaces of the wrists and on the legs, trunk, glands, penis and mucous membrane of the mouth and vagina. (For more information on this disorder, choose "Lichen Planus" as your search term in the Rare Disease Database.)
Patients with Bowenoid Papulosis should be monitored carefully. In some cases Bowenoid Papulosis may heal spontaneously (without treatment). Sexual activity should be limited in order to avoid infecting other people during the contagious stages of this disorder.
Electrosurgery, cryosurgery (surgery in which the tissue is frozen with liquid nitrogen), and/or lazer surgery may be used to remove the lesions when necessary.
In some milder cases the use of 5-Fluorouracil (a chemical that prevents cell division) in the form of a topical cream has been successful.
Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. All studies receiving U.S. government funding, and some supported by private industry, are posted on this government web site.
For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:
Tollfree: (800) 411-1222
TTY: (866) 411-1010
For information about clinical trials sponsored by private sources, contact:
Champion RH, et al., eds. Textbook of Dermatology. 5th ed. Cambridge, MA: Blackwell Scientific Publications; 1992:2819, 2854.
Habif TP, ed. Clinical Dermatology. 2nd ed. St. Louis, MO: The C.V. Mosby Company; 1990:246.
Jablonska S, et al., Bowenoid papulosis transforming into squamous cell carcinoma of the genitalia. Br J Dermatol. 1999;141:576-77.
Johnson TM, et al., Isolated extragenital bowenoid papulosis of the neck. J Am Acad Dermatol. 1999;41:867-70.
Olhoffer IH, et al., Facial bowenoid papulosis secondary to human papillomavirus type 16. Br J Dermatol. 1999;140:761-62.
Bhojwani A, et al., Bowenoid papulosis of the penis. Br J Urol. 1997;80:508.
Sarmiento JM, et al., Perianal Bowen's disease: associated tumors, human papillomavirus, surgery, and other controversies. Dis Colon Rectum. 1997;40:912-18.
Sexuality Information and Education Council of the U.S.
90 John St.
New York, NY 10038
Centers for Disease Control and Prevention
1600 Clifton Road NE
Atlanta, GA 30333
NIH/National Institute of Allergy and Infectious Diseases
NIAID Office of Communications and Government Relations
5601 Fishers Lane, MSC 9806
Bethesda, MD 20892-9806
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders, Inc.® (NORD). Cigna members can access the complete report by logging into myCigna.com. For non-Cigna members, a copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html.
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email email@example.com
Last Updated: 5/12/2009
Copyright 1992, 2000, 2009 National Organization for Rare Disorders, Inc.
Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.