National Organization for Rare Disorders, Inc.
- Hypoplasia of the Depressor Anguli Oris Muscle with Cardiac Defects
- Asymmetric Crying Facies with Cardiac Defects
- ACF with Cardiac Defects
- Cayler Cardiofacial Syndrome
Cayler syndrome, also known as "asymmetric crying facies with cardiac defects," is an extremely rare disorder characterized by congenital heart defects and the underdevelopment or absence of one of the muscles that control the movements of the lower lip. The disorder is present at birth (congenital) and is usually first noticed when the infant cries or smiles. Half of the lower lip cannot be drawn down and outward because of the incomplete development (hypoplasia) or absence (agenesis) of the depressor anguli oris muscle.
Congenital heart defects associated with Cayler syndrome may include ventricular septal defects, atrial septal defects, and/or tetralogy of Fallot. In some rare cases, individuals may have an abnormally small head (microcephaly), unusually small jawbones (micrognathia), small eyes (microphthalmos), and/or mental retardation. Most cases of Cayler syndrome are thought to be inherited as an autosomal dominant trait.
American Heart Association
7272 Greenville Avenue
Dallas, TX 75231
MUMS National Parent-to-Parent Network
150 Custer Court
Green Bay, WI 54301-1243
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
International 22q11.2 Deletion Syndrome Foundation, Inc.
P.O. Box 424
Matawan, NJ 07747
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Last Updated: 4/11/2008
Copyright 1996, 2003 National Organization for Rare Disorders, Inc.
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