Chronic Eosinophilic Pneumonia
National Organization for Rare Disorders, Inc.
- Carrington's disease
- idiopathic chronic eosinophilic pneumonia
Chronic eosinophilic pneumonia (CEP) is a rare disorder characterized by the massive accumulation of eosinophils in the lungs (pulmonary eosinophilia). Eosinophils are a type of white blood cell and are part of the immune system. They are usually produced in response to allergens, inflammation or infection (especially parasitic ones) and are particularly active in the respiratory tract. In CEP, eosinophils also accumulate in the bloodstream (peripheral eosinophilia). Common symptoms include shortness of breath (dyspnea), cough, fatigue, night sweats, low grade fevers, and unintended weight loss. The exact cause of CEP is unknown (idiopathic).
CEP was first described as a distinct entity in the medical literature by Carrington, et al. in 1969 when they described nine individuals with the disorder. It is classified as a form of eosinophilic lung disease, a large group of interstitial lung diseases. CEP is different from acute eosinophilic pneumonia (AEP), which is marked by rapid onset, the absence of asthma, a greater potential for acute respiratory failure and no relapse following treatment. For more information on AEP, choose "acute eosinophilic pneumonia" as your search term in the Rare Disease Database.
Centers for Disease Control and Prevention
1600 Clifton Road NE
Atlanta, GA 30333
NIH/National Heart, Lung and Blood Institute
P.O. Box 30105
Bethesda, MD 20892-0105
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Campaign Urging Research for Eosinophilic Disease (CURED)
PO Box 32
Lincolnshire, IL 60069
Cincinnati Center for Eosinophilic Disorders
Cincinnati Children's Hospital Medical Center
3333 Burnet Avenue
Cincinnati, OH 45229-3039
American Partnership for Eosinophilic Disorders
PO Box 29545
Atlanta, GA 30359
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Last Updated: 3/1/2012
Copyright 2012 National Organization for Rare Disorders, Inc.