Condyloma

Condyloma

National Organization for Rare Disorders, Inc.

Important

It is possible that the main title of the report Condyloma is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • Condyloma Acuminatum
  • Genital Wart
  • Venereal Wart

Disorder Subdivisions

  • None

General Discussion

Condyloma is an infectious disease, usually transmitted by direct sexual contact, that is characterized by the presence of warts caused by the human papilloma virus (HPV). These warts may be found on the genitals, mucous membranes of the mouth, near the anus, or in the rectum.

Symptoms

The warts associated with condyloma appear as small, soft, moist, pink or red elevations on the skin or mucous membranes. They are caused by direct contact with one of the following types of the human papilloma virus (HPV): types 1, 2, 6, 11, 16, or 18. There is an incubation period of 1 to 6 months. The warts are not painful but they can spread rapidly on the genitals, mucous membranes, around the anus, and in the rectum. Occasionally, there may be a single wart, but most often they cluster together, taking on a cauliflower-like appearance.



In females, condyloma can be found on the walls of the vagina or cervix, on the area between the vulva and anus (perineum), or in the rectum. Pregnancy or a chronic vaginal discharge appear to cause these warts to grow and spread more rapidly. Regular examinations, including pap smears, are important for women who have had venereal warts. The increased number of cases of cervical cancer in women with condyloma is evidence of a connection between cancer and the HPV virus.



Men who have been infected with the human papilloma virus may have condyloma warts around the foreskin and/or shaft of the penis, around the anus or in the rectum. Occasionally, they may involve the urethra, the tube that extends through the penis into the bladder allowing urination.

Causes

Condyloma is one of the most common sexually transmitted diseases in the USA today. Its incidence is on the rise, and it affects both men and women. It is caused by the human papilloma virus (HPV) and is transmitted by direct sexual contact.

Affected Populations

Condyloma is an infectious disease that affects males and females equally. Sexual practices that are considered high risk, multiple sexual partners, poor personal hygiene, and engaging in sexual activity at an early age have all been implicated in the increase in incidence of this viral disease. Pregnant women are more prone to this disease, and if not adequately treated, can transmit the virus to the baby at the time of delivery (laryngeal papillomas). Rectal and anal warts are more commonly found among homosexual males.



In the USA, the incidence of condyloma acuminatum has been estimated at 1% of the population. Highest prevalence and risk is among young adults (20-35) and older teenagers (16-19). In the past twenty years, the number of cases of genital warts reported has increased by more than 400 percent.

Standard Therapies

Diagnosis

The diagnosis is made by inspection of the affected area. The presence of small pink or red bumps is usually obvious.



Treatment

Since condyloma is a sexually transmitted disease, both partners should be examined and treated. Treatment of condyloma consists of topical medications such as podophyllin or trichloroacetic acids. This treatment may need to be repeated to assure complete removal of the warts. Genital warts may also be treated under local or general anesthesia by an exposure to extreme cold (cryosurgery), or by cauterizing the wart with heat from an electric current (electrocauterization) or laser therapy. Surgical removal may be necessary for the more extensive cases of this disease. Condylomas may be difficult to treat, and relapses may occur. Several treatments may be necessary. However, early detection and treatment are important. Notification of sexual partners is also important. Circumcision may help to prevent a recurrence of this disease in men. Condoms, used correctly, can give some protection and help to avoid re-infection from this and other sexually-transmitted diseases.



Those people who have been diagnosed with the papilloma virus (types 6, 11, 16, and 18), and their sexual partners, should be followed closely by their physicians. This is due to the fact that certain forms of cancer have occurred after a history of genital warts.

Investigational Therapies

Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. All studies receiving U.S. government funding, and some supported by private industry, are posted on this government web site.



For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:



Tollfree: (800) 411-1222

TTY: (866) 411-1010

Email: prpl@cc.nih.gov



For information about clinical trials sponsored by private sources, contact:

www.centerwatch.com

References

TEXTBOOKS

Beers MH, Berkow R., eds. The Merck Manual, 17th ed. Whitehouse Station, NJ: Merck Research Laboratories; 1999:1338-39; 1953.



Berkow R., ed. The Merck Manual-Home Edition.2nd ed. Whitehouse Station, NJ: Merck Research Laboratories; 2003:.



Larson DE. ed. Mayo Clinic Family Health Book. New York, NY: William Morrow and Company, Inc; 1996:1092; 1171-72.



Fauci AS, Braunwald E, Isselbacher KJ, et al. Eds. Harrison's Principles of Internal Medicine. 14th ed.McGraw-Hill Companies. New York, NY; 1998:1745-46.



Gorbach SL, Bartlett JG, Blacklow NR. Eds. Infectious Diseases. W.B. Saunders Company, Philadelphia, PA; 1992:852-56.



Mandell GL, Bennett JE, Dolan R. Eds. Mandell, Douglas and Bennett's Principles and Practice of Infectious Diseases. 4th ed. Churchill Livingstone Inc. New York, NY; 1995:1392-93.



REVIEW ARTICLES

Wiatrak BJ. Overview of recurrent respiratory papillomatosis. Curr Opin Otolaryngol Head neck Surg. 2003;11:433-41.



Hengge UR, Cusini M. Topical immunomodulators for the treatment of external genital warts, cutaneous warts and molluscum contagiosum. Br J Dermatol. 2003;149 Suppl 66:15-19.



Gunter J. Genital and perianal warts: new treatment opportunities for human papillomavirus infection. Am J Obstet Gynecol. 2003; 189(3 Suppl):S3-11.



Toro JR, Sanchez S, Turiansky G, et al. Topical cidofovir for the treatment of dermatological conditions: verruca, condyloma, intraepithelial neoplasia, herpes simplex and its [potential use in smallpox. Dermatol Clin. 2002;21:301-09.



Frega A, Stentella P, Tinari A, et al. Giant condyloma acuminatum or Buschke-Lowenstein tumor: review of the literature and report of three cases treated by CO2 laser surgery. A long-term follow-up. Anticancer Res. 2002;22:1201-04.



Trombetta LJ, Place RJ. Giant condyloma acuminatum of the anorectum: trends in epidemiology and management: report of a case and review of the literature. Dis Colon Rectum. 2001;44:1878-86.



Von Krogh G, Longstaff E. Podophyllin office therapy against condyloma should be abandoned. Sex Transm Infect. 2001;77:409-12.



Baldwin HE. STD update: screening and therapeutic options. Int J Fertil Womens Med. 2001;46:79-88.



FROM THE INTERNET

Higgins RV. Naumann W, Hall J. Condyloma Acuminata. emedicine. Last Updated: January 17, 2002. 18pp.

www.emedicine.com/med/topic3293.htm



Kazzi AA, Ghadishah D. Condyloma Acuminata. emedicine. Last Updated: July 3, 2001. 15pp.

www.emedicine.com/EMERG/topic107.htm



What is Condyloma. Last modified: January 10, 2001. 3pp.

www.condyloma.org/main.html



Condyloma Treatment. Virtual Hospital. Last Revision Date: February 2002. 3pp.

www.vh.org/adult/patient/obgyn/condyloma/



Condyloma (Genital Warts) Treatment. University of Iowa Health Care. nd. 2pp.

www.obgyn.uihc.uiowa.edu/Patinfo/STD/warts.htm



Genital Warts. AllRefer.com Health. Review Date: 8/8/2003. various pp.

http://health.allrefer.com/health/genital-warts-info.html

Resources

Sexuality Information and Education Council of the U.S.

90 John St.

Suite 704

New York, NY 10038

Tel: (212)819-9770

Fax: (212)819-9776

Email: pmalone@siecus.org

Internet: http://www.siecus.org



Centers for Disease Control and Prevention

1600 Clifton Road NE

Atlanta, GA 30333

Tel: (404)639-3534

Tel: (800)232-4636

TDD: (888)232-6348

Email: cdcinfo@cdc.gov

Internet: http://www.cdc.gov/



NIH/National Institute of Allergy and Infectious Diseases

Office of Communications and Government Relations

6610 Rockledge Drive, MSC 6612

Bethesda, MD 20892-6612

Tel: (301)496-5717

Fax: (301)402-3573

Tel: (866)284-4107

TDD: (800)877-8339

Email: ocpostoffice@niaid.nih.gov

Internet: http://www.niaid.nih.gov/



American Social Health Association

P.O. Box 13827

Research Triangle Park, NC 27709

Tel: (919)361-8400

Fax: (919)361-8425

Email: customerservice@ashastd.org

Internet: http://www.ashastd.org



Genetic and Rare Diseases (GARD) Information Center

PO Box 8126

Gaithersburg, MD 20898-8126

Tel: (301)251-4925

Fax: (301)251-4911

Tel: (888)205-2311

TDD: (888)205-3223

Internet: http://rarediseases.info.nih.gov/GARD/



For a Complete Report

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