National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Condyloma is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Related Disorders List
Information on the following diseases can be found in the Related Disorders section of this report:
- Common Warts
- Bowen's Disease
- Herpes Simplex
- Squamous Cell Carcinoma
Condyloma is an infectious disease, usually transmitted by direct sexual contact, that is characterized by the presence of warts caused by the human papilloma virus (HPV). These warts may be found on the genitals, mucous membranes of the mouth, near the anus, or in the rectum.
The warts associated with condyloma appear as small, soft, moist, pink or red elevations on the skin or mucous membranes. They are caused by direct contact with one of the following types of the human papilloma virus (HPV): types 1, 2, 6, 11, 16, or 18. There is an incubation period of 1 to 6 months. The warts are not painful but they can spread rapidly on the genitals, mucous membranes, around the anus, and in the rectum. Occasionally, there may be a single wart, but most often they cluster together, taking on a cauliflower-like appearance.
In females, condyloma can be found on the walls of the vagina or cervix, on the area between the vulva and anus (perineum), or in the rectum. Pregnancy or a chronic vaginal discharge appear to cause these warts to grow and spread more rapidly. Regular examinations, including pap smears, are important for women who have had venereal warts. The increased number of cases of cervical cancer in women with condyloma is evidence of a connection between cancer and the HPV virus.
Men who have been infected with the human papilloma virus may have condyloma warts around the foreskin and/or shaft of the penis, around the anus or in the rectum. Occasionally, they may involve the urethra, the tube that extends through the penis into the bladder allowing urination.
Condyloma is one of the most common sexually transmitted diseases in the USA today. Its incidence is on the rise, and it affects both men and women. It is caused by the human papilloma virus (HPV) and is transmitted by direct sexual contact.
Condyloma is an infectious disease that affects males and females equally. Sexual practices that are considered high risk, multiple sexual partners, poor personal hygiene, and engaging in sexual activity at an early age have all been implicated in the increase in incidence of this viral disease. Pregnant women are more prone to this disease, and if not adequately treated, can transmit the virus to the baby at the time of delivery (laryngeal papillomas). Rectal and anal warts are more commonly found among homosexual males.
In the USA, the incidence of condyloma acuminatum has been estimated at 1% of the population. Highest prevalence and risk is among young adults (20-35) and older teenagers (16-19). In the past twenty years, the number of cases of genital warts reported has increased by more than 400 percent.
Symptoms of the following disorders can be similar to those of Condyloma. Comparisons may be useful for a differential diagnosis.
Bowen's Disease is a precancerous, slow growing skin malignancy. It is characterized by irregularly shaped, pinkish or brownish raised areas of skin (papules). This skin disease can occur on any part of the body, in the mucous membranes or on the genitals. (For more information on this disorder, choose "Bowen" as your search term in the Rare Disease Database.)
Common Warts or verruca are small hard raised growths on the surface of the skin. These growths are caused by a virus and can appear on any part of the body. Warts can vary from normal skin color to a dark brown-black and occur most often on the fingers, elbows, and knees. Less frequently they can occur on the face and around the edges of the nails.
Herpes Simplex is a common recurrent infection by the herpes simplex virus. It is characterized by clusters of small blisters filled with clear fluid on slightly red bases. These blisters can appear on the skin, mucous membranes and the genital area. The virus is transmitted by direct contact with the lesions, sometimes during sexual contact.
Squamous Cell Carcinomas are common skin cancers usually appearing on the sun exposed areas of the skin. However they may occur anywhere on the body, including the genitals. The lesions begin as a small red elevation or patch with a scaly or crusted surface. They may become nodular, sometimes with a warty surface. In some, the bulk of the lesion may lie below the level of the surrounding tissue. A biopsy is essential to diagnose this disorder.
The diagnosis is made by inspection of the affected area. The presence of small pink or red bumps is usually obvious.
Since condyloma is a sexually transmitted disease, both partners should be examined and treated. Treatment of condyloma consists of topical medications such as podophyllin or trichloroacetic acids. This treatment may need to be repeated to assure complete removal of the warts. Genital warts may also be treated under local or general anesthesia by an exposure to extreme cold (cryosurgery), or by cauterizing the wart with heat from an electric current (electrocauterization) or laser therapy. Surgical removal may be necessary for the more extensive cases of this disease. Condylomas may be difficult to treat, and relapses may occur. Several treatments may be necessary. However, early detection and treatment are important. Notification of sexual partners is also important. Circumcision may help to prevent a recurrence of this disease in men. Condoms, used correctly, can give some protection and help to avoid re-infection from this and other sexually-transmitted diseases.
Those people who have been diagnosed with the papilloma virus (types 6, 11, 16, and 18), and their sexual partners, should be followed closely by their physicians. This is due to the fact that certain forms of cancer have occurred after a history of genital warts.
Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. All studies receiving U.S. government funding, and some supported by private industry, are posted on this government web site.
For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:
Tollfree: (800) 411-1222
TTY: (866) 411-1010
For information about clinical trials sponsored by private sources, contact:
Beers MH, Berkow R., eds. The Merck Manual, 17th ed. Whitehouse Station, NJ: Merck Research Laboratories; 1999:1338-39; 1953.
Berkow R., ed. The Merck Manual-Home Edition.2nd ed. Whitehouse Station, NJ: Merck Research Laboratories; 2003:.
Larson DE. ed. Mayo Clinic Family Health Book. New York, NY: William Morrow and Company, Inc; 1996:1092; 1171-72.
Fauci AS, Braunwald E, Isselbacher KJ, et al. Eds. Harrison's Principles of Internal Medicine. 14th ed.McGraw-Hill Companies. New York, NY; 1998:1745-46.
Gorbach SL, Bartlett JG, Blacklow NR. Eds. Infectious Diseases. W.B. Saunders Company, Philadelphia, PA; 1992:852-56.
Mandell GL, Bennett JE, Dolan R. Eds. Mandell, Douglas and Bennett's Principles and Practice of Infectious Diseases. 4th ed. Churchill Livingstone Inc. New York, NY; 1995:1392-93.
Wiatrak BJ. Overview of recurrent respiratory papillomatosis. Curr Opin Otolaryngol Head neck Surg. 2003;11:433-41.
Hengge UR, Cusini M. Topical immunomodulators for the treatment of external genital warts, cutaneous warts and molluscum contagiosum. Br J Dermatol. 2003;149 Suppl 66:15-19.
Gunter J. Genital and perianal warts: new treatment opportunities for human papillomavirus infection. Am J Obstet Gynecol. 2003; 189(3 Suppl):S3-11.
Toro JR, Sanchez S, Turiansky G, et al. Topical cidofovir for the treatment of dermatological conditions: verruca, condyloma, intraepithelial neoplasia, herpes simplex and its [potential use in smallpox. Dermatol Clin. 2002;21:301-09.
Frega A, Stentella P, Tinari A, et al. Giant condyloma acuminatum or Buschke-Lowenstein tumor: review of the literature and report of three cases treated by CO2 laser surgery. A long-term follow-up. Anticancer Res. 2002;22:1201-04.
Trombetta LJ, Place RJ. Giant condyloma acuminatum of the anorectum: trends in epidemiology and management: report of a case and review of the literature. Dis Colon Rectum. 2001;44:1878-86.
Von Krogh G, Longstaff E. Podophyllin office therapy against condyloma should be abandoned. Sex Transm Infect. 2001;77:409-12.
Baldwin HE. STD update: screening and therapeutic options. Int J Fertil Womens Med. 2001;46:79-88.
FROM THE INTERNET
Higgins RV. Naumann W, Hall J. Condyloma Acuminata. emedicine. Last Updated: January 17, 2002. 18pp.
Kazzi AA, Ghadishah D. Condyloma Acuminata. emedicine. Last Updated: July 3, 2001. 15pp.
What is Condyloma. Last modified: January 10, 2001. 3pp.
Condyloma Treatment. Virtual Hospital. Last Revision Date: February 2002. 3pp.
Condyloma (Genital Warts) Treatment. University of Iowa Health Care. nd. 2pp.
Genital Warts. AllRefer.com Health. Review Date: 8/8/2003. various pp.
Sexuality Information and Education Council of the U.S.
90 John St.
New York, NY 10038
Centers for Disease Control and Prevention
1600 Clifton Road NE
Atlanta, GA 30333
NIH/National Institute of Allergy and Infectious Diseases
NIAID Office of Communications and Government Relations
5601 Fishers Lane, MSC 9806
Bethesda, MD 20892-9806
American Social Health Association
P.O. Box 13827
Research Triangle Park, NC 27709
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders, Inc.® (NORD). Cigna members can access the complete report by logging into myCigna.com. For non-Cigna members, a copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html.
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email firstname.lastname@example.org
Last Updated: 5/15/2009
Copyright 1990, 1995, 2004, 2009 National Organization for Rare Disorders, Inc.
Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.