Jarcho-Levin Syndrome

Jarcho-Levin Syndrome

National Organization for Rare Disorders, Inc.

Important

It is possible that the main title of the report Jarcho-Levin Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • spondylocostal dysplasia
  • spondylothoracic dysplasia
  • costovertebral segmentation anomalies
  • spondylocostal dysostosis
  • spondylothoracic dysostosis

Disorder Subdivisions

  • SCDO1
  • SCDO2

General Discussion

Jarcho-Levin syndrome is a rare genetic disorder characterized by distinctive malformations of bones of the spinal column (vertebrae) and the ribs, respiratory insufficiency, and/or other abnormalities. Infants born with Jarcho-Levin syndrome have short necks, limited neck motion due to abnormalities of the cervical vertebrae and short stature.



In most cases, infants with Jarcho-Levin syndrome experience respiratory insufficiency and are prone to repeated respiratory infections (pneumonia) that result in life-threatening complications. The vertebrae are fused and the ribs fail to develop properly, therefore, the chest cavity is too small to accommodate the growing lungs.



There are apparently two forms of Jarcho-Levin Syndrome that are inherited as autosomal recessive genetic traits and termed spondylocostal dysostosis type 1 (SCDO1) and spondylocostal dyostosis type 2 (SCDO2).

Symptoms

Jarcho-Levin Syndrome is characterized by multiple skeletal deformities caused by fused and/or malformed vertebrae, small, malformed or missing ribs, and a chest cavity that is to small for the infant's lungs especially as the lungs grow. There is incomplete development (dysplasia) of one side of certain vertebrae (hemivertebrae), fusion of certain ribs, and/or other rib malformations. Consequently the infant is subject to repeated and severe infections of the lungs (pneumonia).



As a result of these developmental problems, the neck, trunk and torso appear to be short so that patients are considered to be of "short stature" or dwarfs. The fingers are usually webbed (syndactyly), elongated and permanently bent (camptodactyly).



In addition, symptoms may include a broad forehead, a wide nasal bridge, nostrils that are tipped forward (anteverted nares), upwardly slanted eyelids, and an enlarged posterior skull. Occasionally distention of the stomach and pelvis may occur due to an obstruction of the bladder. Undescended testicles, absent external genitalia, a double uterus, closed or absent anal and bladder openings, a single umbilical artery, and defects of the brain may also be present.



SCDO2 is milder than SCDO1 in that not all vertebrae are affected.

Causes

There are two forms of Jarcho-Levin syndrome that are transmitted as autosomal recessive genetic traits. SCDO1 is caused by an abnormality in the DLL3 gene located on chromosome 19 at 19q13. SCDO2 is caused by an abnormality in the MESP2 gene located on chromosome 15 at 15q26.1.



Chromosomes, which are present in the nucleus of human cells, carry the genetic information for each individual. Human body cells normally have 46 chromosomes. Pairs of human chromosomes are numbered from 1 through 22 and the sex chromosomes are designated X and Y. Males have one X and one Y chromosome and females have two X chromosomes. Each chromosome has a short arm designated "p" and a long arm designated "q". Chromosomes are further sub-divided into many bands that are numbered. For example, "chromosome 19q13" refers to band 13 on the long arm of chromosome 19. The numbered bands specify the location of the thousands of genes that are present on each chromosome.



Genetic diseases are determined by the combination of genes for a particular trait that are on the chromosomes received from the father and the mother.



Recessive genetic disorders occur when an individual inherits the same abnormal gene for the same trait from each parent. If an individual receives one normal gene and one gene for the disease, the person will be a carrier for the disease, but usually will not show symptoms. The risk for two carrier parents to both pass the defective gene and, therefore, have an affected child is 25% with each pregnancy. The risk to have a child who is a carrier like the parents is 50% with each pregnancy. The chance for a child to receive normal genes from both parents and be genetically normal for that particular trait is 25%. The risk is the same for males and females.



All individuals carry 4-5 abnormal genes. Parents who are close relatives (consanguineous) have a higher chance than unrelated parents to both carry the same abnormal gene, which increases the risk to have children with a recessive genetic disorder.

Affected Populations

Jarcho-Levin Syndrome is a very rare disorder that affects males and females in equal numbers. There seems to be a higher incidence of this disorder in people with Spanish heritage.

Standard Therapies

Diagnosis

Jarcho-Levin syndrome is diagnosed by the presence of abnormalities in the spine, back and chest that are present at birth. Diagnosis can sometimes be made prenatally by ultrasound examination.



Treatment

Treatment of Jarcho-Levin syndrome is sympathetic and supportive. Genetic counseling may be of benefit for families of people with this disorder.



The Vertical Expandable Prosthetic Titanium Rib (VEPTR) was approved by the FDA in 2004 as a treatment for thoracic insufficiency syndrome (TIS) in pediatric patients. TIS is a congenital condition where severe deformities of the chest, spine, and ribs prevent normal breathing and lung development. The VEPTR is an implanted, expandable device that helps straighten the spine and separate ribs so that the lungs can grow and fill with enough air to breathe. The length of the device can be adjusted as the patient grows. The titanium rib was developed at the University of Texas Health Science Center in San Antonio. It is manufactured by Synthes Spine Co.: http://www.synthes.com/sites/NA/Products/Spine/Screw_Hook_Rod_and_Clamp_System/Pages/VEPTR_and_VEPTR_II.aspx



For more information, please contact:



Synthes, Inc.

1302 Wrights Lane East

West Chester, PA 19380

800-523-0322

Investigational Therapies

Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. All studies receiving U.S. government funding, and some supported by private industry, are posted on this government web site.



For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:



Tollfree: (800) 411-1222

TTY: (866) 411-1010

Email: prpl@cc.nih.gov



For information about clinical trials sponsored by private sources, contact:

www.centerwatch.com

References

TEXTBOOK

Jones KL. Ed. Smith's Recognizable Patterns of Human Malformation. 5th ed. W. B. Saunders Co., Philadelphia, PA; 1997:598.



JOURNAL ARTICLES

Whittock NV, Sparrow DB, Wouters MA, et al. Mutated MESP2 causes spondylocostal dysostosis. Am J Hum Genet. 2004;74:1249-54.



Teli M, Hosalkar H, Gill I, et al. Spondylocostal dysostosis: thirteen new cases treated by conservative and surgical means. Spine. 2004;29:1447-51.



Cornier AS, Ramirez N, Arroyo S, et al. Phenotype characterizations and natural history of spondylothoracic dysplasia syndrome: a series of 27 new cases. Am J Med Genet. 2004;128A:120-26.



Kauffmann E, Roman H, Barau G, et al. Case Report: a prenatal case of Jarcho-Levin syndrome diagnosed during the first trimester of pregnancy. Prenat Diagn. 2003;23:163-65.



Tubbs RS, Wellons JC3rd, Blount JP, et al. Jarcho-Levin syndrome. Pediatr Neurosurg. 2002;36:279.



FROM THE INTERNET

McKusick VA, Ed. Online Mendelian Inheritance in Man (OMIM). The Johns Hopkins University. Spondylocostal Dysostosis, Autosomal Recessive 1, SCDO1. Entry Number; 277300: Last Edit Date; 8/26/2004.



McKusick VA, Ed. Online Mendelian Inheritance in Man (OMIM). The Johns Hopkins University. Spondylocostal Dysostosis, Autosomal Recessive 2, SCDO2. Entry Number; 608681: Last Edit Date; 6/4/2004.



McKusick VA, Ed. Online Mendelian Inheritance in Man (OMIM). The Johns Hopkins University. Costovertebral Segmentation Anomalies. Entry Number; 122600: Last Edit Date; 3/17/2004.



Letts RM, Jawadi AH, Congenital Spinal Deformity. emedicine. Last Updated: September 16, 2004. 32pp.

www.emedicine.com/orthoped/topic618.htm



Jarcho-Levin Syndrome. Orphanet. January 2004. 1pp.

www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=2311



The Titanium Rib Project. nd. multiple.

http://www.titaniumribproject.8m.com/

Resources

Restricted Growth Association

PO Box 5137

Yeovil, BA20 9FF

United Kingdom

Tel: 03001111970

Fax: 03001112454

Email: office@restrictedgrowth.co.uk

Internet: http://www.restrictedgrowth.co.uk



Genetic and Rare Diseases (GARD) Information Center

PO Box 8126

Gaithersburg, MD 20898-8126

Tel: (301)251-4925

Fax: (301)251-4911

Tel: (888)205-2311

TDD: (888)205-3223

Internet: http://rarediseases.info.nih.gov/GARD/



Madisons Foundation

PO Box 241956

Los Angeles, CA 90024

Tel: (310)264-0826

Fax: (310)264-4766

Email: getinfo@madisonsfoundation.org

Internet: http://www.madisonsfoundation.org



European Skeletal Dysplasia Network

Institute of Genetic Medicine

Newcastle University

International Centre for Life

Central Parkway

Newcastle upon Tyne, NE1 3BZ

United Kingdom

Tel: 441612755642

Fax: 441612755082

Email: info@esdn.org

Internet: http://www.esdn.org



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc.® (NORD). Cigna members can access the complete report by logging into myCigna.com. For non-Cigna members, a copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html.

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