Klüver-Bucy Syndrome

National Organization for Rare Disorders, Inc.

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It is possible that the main title of the report Klüver-Bucy Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.


  • bilateral temporal lobe disorder

Disorder Subdivisions

  • None

General Discussion

Klüver-Bucy syndrome is a very rare cerebral neurological disorder associated with damage to both temporal lobes resulting in abnormalities in memory, social and sexual functioning and idiosyncratic behaviors.


Major symptoms may include excessive oral tendencies with an urge to put all kinds of objects into the mouth, hypermetamorophosis (a need to explore everything), memory loss, emotional changes, extreme sexual behavior, indifference, placidity, visual distractibility and visual agnosia (difficulty identifying and processing visual information). An almost uncontrollable appetite for food may also be noted. There may also be other symptoms associated with dementia (loss of reason) as well.


Klüver-Bucy syndrome is the result of damage to the temporal lobes of the brain. This may be the result of trauma to the brain itself, or the result of other degenerative brain diseases, tumors, or it can be caused by some brain infections, most commonly herpes simplex encephalitis (a viral brain infection).

Affected Populations

Klüver-Bucy syndrome is a very rare disease that affects males and females equally.

Standard Therapies

Treatment of Klüver-Bucy syndrome is supportive and psychotropics that may be effective for some of the associated symptoms.

Investigational Therapies

Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. All studies receiving U.S. Government funding, and some supported by private industry, are posted on this government web site.

For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:

Tollfree: (800) 411-1222

TTY: (866) 411-1010

Email: prpl@cc.nih.gov

For information about clinical trials sponsored by private sources, contact:




Adams RD, et al., eds. Principles of Neurology, 6th ed. New York, NY: McGraw-Hill Companies; 1997:450,517.


Carroll BT, et al., Anatomic basis of Klüver-Bucy syndrome. J NeuropsychiatryClin Neurosci. 1999;11:116.

Slaughter J, et al., Selective serotonin reuptake inhibitor treatment of post-traumatic Klüver-Bucy syndrome. Brain Inj. 1999;13:59-62.

Pradhan S. et al., Klüver Bucy syndrome in young children. Clin Neurol Neurosurg. 1998;100:254-58.

Hayman LA, et al., Klüver Bucy syndrome after bilateral selective damage of amygdala and its cortical connections. J Neuropsychiatry Clin Neurosci. 1998;10:354-58.

Goscinski I, et al., The Klüver-Bucy syndrome. J Neurol. 1997;41:269-72.


NINDS Klüver-Bucy Syndrome Information Page


Last updated July 2, 2008. Accessed February 9, 2012.


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For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc.® (NORD). Cigna members can access the complete report by logging into myCigna.com. For non-Cigna members, a copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html.