Lupus and Antiphospholipid Antibody Syndrome

Skip to the navigation

Topic Overview

About 1 out of 3 people with lupus produce an antibody that attacks certain blood-clotting factors, which can cause the blood to clot easily. footnote 1 A person who has this antibody and has had blood clots is said to have antiphospholipid antibody syndrome. This can lead to mild or severe blood-clotting complications, including:

A blood test can detect antiphospholipid antibodies. When diagnosed, the condition is usually treated with anticoagulants . Pregnant women with antiphospholipid antibody syndrome need to be closely monitored.



  1. Crow MK (2016). Systemic lupus erythematosus. In L Goldman, A Shafer, eds., Goldman-Cecil Medicine, 24th ed., vol. 2, pp. 1769–1777. Philadelphia: Saunders.


ByHealthwise Staff

Primary Medical Reviewer Anne C. Poinier, MD - Internal Medicine

Martin J. Gabica, MD - Family Medicine

E. Gregory Thompson, MD - Internal Medicine

Specialist Medical Reviewer Nancy Ann Shadick, MD, MPH - Internal Medicine, Rheumatology

Current as ofMay 11, 2016