Mallory Weiss Syndrome

National Organization for Rare Disorders, Inc.

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It is possible that the main title of the report Mallory Weiss Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.


  • Gastroesophageal Laceration-Hemorrhage
  • Mallory-Weiss Laceration
  • Mallory-Weiss Tear

Disorder Subdivisions

  • None

General Discussion

Mallory-Weiss syndrome refers to a tear or laceration of the mucous membrane, most commonly at the point where the esophagus and the stomach meet (gastroesophageal junction). Such a tear may result in severe bleeding from the gastrointestinal tract. The immediate cause of the lesion is usually a protracted period of vomiting.


Mallory-Weiss syndrome is most commonly characterized by abdominal pain, a history of severe vomiting, vomiting of blood (hematemesis), and the strong involuntary effort to vomit (retching). The blood is often clotted and has the appearance of "coffee grounds". The stools may be as dark as tar (melenic). In cases in which there is substantial loss of blood, there may be shock and collapse.

Individuals with Mallory-Weiss syndrome may also experience severe, painless internal gastrointestinal bleeding (hemorrhaging) due to the tears in the mucous membranes. In most cases (80-90%) however, such bleeding ceases spontaneously. In very rare cases, the bleeding may become life-threatening.


In most instances, the immediate cause of Mallory-Weiss syndrome is severe vomiting. This can be associated with chronic alcoholism, but MWS may also result from a severe trauma to the chest or abdomen, chronic hiccups, intense snoring, lifting and straining, inflammation of the lining of the stomach (gastritis) or esophagus (esophagitis), hiatus hernia, convulsions or CPR (cardiopulmonary resuscitation). Cancer patients undergoing chemotherapy may develop this disorder as a complication of chemotherapy.

Affected Populations

Mallory-Weiss syndrome accounts for 1 to 15% of all gastrointestinal bleeding episodes. However, it occurs more frequently in individuals with alcoholism. MWS appears to affect more males then females. The ages of those affected varies considerably, with a peak at ages 40 through 60. However, some cases have been reported in children.

Standard Therapies


The diagnosis of Mallory-Weiss syndrome is usually determined by endoscopic examination of the esophagus membrane.


In many cases, bleeding caused by Mallory-Weiss syndrome will stop without treatment. In cases where the bleeding persists, treatment may include sealing the lesion by applying heat or chemicals (cauterization) or high frequency electrical current (electrocoagulation). Blood transfusions and/or the use of the vasopressive drug, pitressin, may be required. (Among other actions, the hormone pitressin acts upon the muscles of the capillaries to affect blood pressure.) Direct pressure may also be used by inserting a catheter which is surrounded by a balloon. The balloon is then inflated (balloon tamponade) to stop the bleeding. Surgery is usually not necessary unless the bleeding cannot be controlled by conservative measures. Other treatment is symptomatic and supportive.

Embolization may be necessary as a treatment for massive uncontrolled bleeding of the esophagus. This procedure consists of inserting a substance, such as gelfoam, bucrylate, or alcohol (ethanol) and stainless steel coils into the affected area.

Investigational Therapies

Information on current clinical trials is posted on the Internet at All studies receiving U.S. government funding, and some supported by private industry, are posted on this government web site.

For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:

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For information about clinical trials sponsored by private sources, contact:



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Mallory-Weiss Syndrome. nd. 1p.


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