Multiple Sclerosis: Medicines for Fatigue

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Topic Overview

Medicines used to treat fatigue caused by multiple sclerosis (MS) include:

  • Amantadine. This medicine typically has few side effects. When they do occur, they may include dry mouth, blurred vision, urinary retention, fluid retention, and rash.
  • Fluoxetine (Prozac). This antidepressant may help reduce fatigue in some people who have MS.
  • Modafinil (Provigil). This medicine is used to treat narcolepsy . It has also been used by doctors to treat fatigue in MS.

Related Information


ByHealthwise Staff

Primary Medical Reviewer Adam Husney, MD - Family Medicine

Anne C. Poinier, MD - Internal Medicine

Specialist Medical Reviewer Barrie J. Hurwitz, MD - Neurology

Current as ofFebruary 20, 2015