Pain is a frequent problem for people who have
multiple sclerosis (MS). Medicines that may be used
to bring relief include:
Nonprescription pain relievers. These include
acetaminophen (such as Tylenol), ibuprofen (such as Advil), and naproxen (such as Aleve). Be safe with medicines. Read and follow all instructions on the label.
Amitriptyline, imipramine (Tofranil), or nortriptyline (Pamelor), for burning sensations.
Gabapentin (Neurontin). This drug may also help relieve
muscle stiffness and tightness (
Some forms of natural or man-made substances related to marijuana, called cannabinoids, may help relieve pain.
Pain that does not respond to these medicines can sometimes be
treated with an injection of long-acting anesthetic.
Yadav V, et al. (2014). Summary of evidence-based guideline: Complementary and alternative medicine in multiple sclerosis: Report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology, 82(12): 1083–1092.
ByHealthwise Staff Primary Medical ReviewerAdam Husney, MD - Family Medicine Anne C. Poinier, MD - Internal Medicine Specialist Medical ReviewerBarrie J. Hurwitz, MD - Neurology
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