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It is possible that the main title of the report Posterior Uveitis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Related Disorders List
Information on the following diseases can be found in the Related Disorders section of this report:
- Anterior Uveitis
- Pars Planitis
Uveitis is a general term that refers to inflammation of the part of the eye known as the uvea.
The uvea is a relatively thick, strong layer of fibrous tissue that encloses and protects the eyeball. It consists of three parts: the iris, the ciliary body, and the choroid.
There are three types of uveitis, classified according to the part of the uvea that is affected. Anterior uveitis, which affects the front part of the eye, is also sometimes called iritis since the iris is part of the front of the eye. Intermediate uveitis, also known as pars planitis or cyclitis, refers to inflammation of tissues in the area just behind the iris and lens of the eye. Posterior uveitis, also known as choroiditis, refers to inflammation of the choroid, the back part of the uvea. Posterior uveitis may affect the retina and/or the optic nerve, and may lead to permanent loss of vision.
Posterior uveitis is the rare form of the disorder and is the type of uveitis most associated with loss of vision. The other two forms are more common, and more frequently result in acute symptoms, but only rarely cause vision loss.
Posterior uveitis is usually, but not always, painless. Symptoms typically include "floaters", small specks, flakes, or clouds that move through the field of vision, and decreased vision. While anterior uveitis often causes eye pain and redness, light sensitivity, and blurred vision, the symptoms of posterior uveitis are more subtle.
Uveitis can lead to other complications, including glaucoma, cataracts, or retinal detachment. Early detection and treatment is important to reduce the risk of permanent vision loss.
Posterior uveitis can have infectious or noninfectious causes. Infectious causes include bacterial, fungal, parasitic, and viral infections. Noninfectious causes include immunologic problems, allergies, malignancies, and unknown causes.
One report suggests that about 60% of cases are caused by problems intrinsic to the eye itself and that the other 40% of cases are the result of associated autoimmune disorders, infections, and/or trauma. Some of the disorders with which posterior uveitis is sometimes associated are Behcet's syndrome, ankylosing spondylitis, Lyme disease, sarcoidosis, and psoriasis. Among children, the disorder is frequently associated with juvenile rheumatoid arthritis.
Posterior uveitis occurs as an isolated condition or as part of other disease affecting body systems (systemic). This condition affects males and females in equal numbers. It can strike at almost any age, although it appears most often to occur between the ages of 20 and 50. According to one estimate, chronic, non-infectious posterior uveitis affects 175,000 people in the United States and 800,000 people worldwide. Almost 80% of cases of uveitis affect the front (anterior) portion of the eye.
Symptoms of the following disorders can be similar to those of posterior uveitis. Comparisons may be useful for a differential diagnosis:
Anterior uveitis is characterized by inflammation of the front (anterior) part of the eye. It is more common than is posterior uveitis, and its symptoms, which frequently include pain and redness of the eye, are not as subtle as those of posterior uveitis.
Intermediate uveitis, also known as Pars planitis, is a vision disorder characterized by inflammation of the peripheral retina and pars plana (a section of the ciliary body connected to the retina) sections of the eye. Fluid and foreign cells can infiltrate the clear gelatin-like substance (vitreous humor) near the retina and/or pars plana. Swelling inside the eye can also occur. These abnormalities may appear in one or both eyes. (For more information on this disorder, choose "Pars Planitis" as your search term in the Rare Disease Database.)
The first step in diagnosis is to determine the role, if any, of other immunological and/or infectious conditions in the development of the disorder. Blood studies for infectious agents such as herpes virus, toxoplasmosis, toxocariasis and spirochetes are helpful. Chest x-rays may detect sarcoidosis or tuberculosis. If systemic or central nervous system involvement is present or large cell lymphoma is suspected, neuroimaging studies and lumbar puncture may be used.
It is important to identify and treat an underlying infection or immunological disorder before initiating other treatment. Steroids administered intravenously are often used as a treatment for posterior uveitis. However, long-term use of systemic corticosteroids carries with it the risk of increased pressure in the eye (glaucoma) and cataracts, so the patient must be followed closely.
In April of 2005, the FDA announced the approval of the orphan product Retisert (an implant) for the treatment of chronic, non-infectious posterior uveitis. The implant, a tiny drug reservoir, delivers approximately two-and-a-half years of the anti-inflammatory corticosteroid, fluocinolone acetonide, directly to the back of the eye. For information, contact the manufacturer:
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Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. All studies receiving U.S. government funding, and some supported by private industry, are posted on this government web site.
For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:
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For information about clinical trials sponsored by private sources, contact:
Currently, the National Eye Institute is sponsoring clinical trials involving posterior uveitis. Two of these studies involve the use of a monoclonal antibody as a treatment for posterior uveitis. Monoclonal antibodies are genetically engineered proteins designed to affect a specific target or biochemical reaction within the body. In these trials, the monoclonal antibody is known as daclizumab and it inhibits a specific chemical reaction needed by lymphocytes to produce inflammation. For information about these and other current trials, visit the ClinicalTrails.gov web site or contact the NIH Patient Recruitment Office (see above).
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Ciulla TA, Walker JD, Fong DS, et al. Corticosteroids in posterior segment disease: an update on new delivery systems and new indications. Curr Opin Ophthalmol. 2004;15:211-20.
Ciardella AP, Borodoker N, Costa DL, et al. Imaging the posterior segment in uveitis. Ophthamol Clin North Am. 2002;15:281-96.
Okada AA. Drug therapy in Behcet's disease. Ocul Immunol Inflamm. 2000;8:85-91.
Menezo V, Lau C, Comer M, et al. Clinical outcome of chronic immunosuppression in patients with non-infectious uveitis. Clin Experiment Ophthalmol. 2005;33:16-21.
Chen CS, Robertson D, Hammerton ME. Juvenile arthritis-associated uveitis: visual outcomes and prognosis. Can J Ophthalmol. 2004;39:614-20.
Murphy CC, Greiner K, Plskova J, et al. Neutralizing tumor necrosis factor activity leads to remission in patients with refractory non-infectious posterior uveitis. Arch Ophthalmol. 2004;122:845-51. Erratum in: Arch Ophthalmol. 2004;122:1336.
Lobo A, Barton K, Minassian D, et al. Visual loss in sarcoid-related uveitis. Clin Experiment Ophthalmol. 2003;31:310-16.
Toker E, Kazokoglu H, Acar N. High-dose intravenous therapy for severe posterior segment uveitis in Behcet's disease. Br J Ophthalmol. 2002;86:521-23.
FROM THE INTERNET
Uveitis. University of Maryland Medicine. Review Date: October 2000. 5pp.
Dick AD. Uveitis. Contact a Family. Last reviewed October 2001. 3pp.
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