National Organization for Rare Disorders, Inc.
- Mendenhall syndrome
Rabson-Mendenhall syndrome is an extremely rare genetic disorder characterized by severe insulin resistance. Insulin, a hormone produced by the pancreas, regulates blood sugar levels by promoting the movement of glucose (a simple sugar) into cells for energy production or into the liver and fat cells for storage.
Initial symptoms of Rabson-Mendenhall syndrome include abnormalities of the head and face (craniofacial region), abnormalities of the teeth and nails, and skin abnormalities such as acanthosis nigricans, a skin disorder characterized by abnormally increased coloration (hyperpigmentation) and "velvety" thickening (hyperkeratosis) of the skin, particularly of skin fold regions, such as of the neck, groin, and under the arms. In most cases, additional symptoms are present. Rabson-Mendenhall syndrome is inherited as an autosomal recessive trait.
March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
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American Diabetes Association
1701 N. Beauregard Street
Alexandria, VA 22311
NIH/Child Health and Human Development - Section on Endocrinology and Genetics
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NIH/National Institute of Diabetes, Digestive & Kidney Diseases
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NIH/National Institute of Child Health and Human Development
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Genetic and Rare Diseases (GARD) Information Center
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Last Updated: 3/15/2013
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