National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Roseola Infantum is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Related Disorders List
Information on the following diseases can be found in the Related Disorders section of this report:
- Atypical Measles Syndrome (AMS)
- Measles (Rubeola)
- Rubella (German Measles)
- Scarlet Fever
Roseola Infantum is an acute infectious disorder of infants or very young children. Characterized by high fever and the appearance of a red skin rash, this disorder may resemble Rubella after the fever has disappeared. Seizures may also occur.
The incubation period before symptoms of Roseola Infantum appear is approximately 5 to 15 days. A high fever begins abruptly and usually lasts for 3 or 4 days without an obvious identifiable cause. Convulsions are common during this period. Low levels of white blood cells (leukopenia) may occur by the 3rd day. The spleen may be slightly enlarged. The fever usually breaks on the 4th day, and a characteristic rash of red spots or elevated (macular or maculopapular) spots appears. This rash may cover the chest and abdomen, although it often appears in a mild form on the face and extremities. Temperature returns to normal at this stage, and the child usually feels and acts well. In some cases, the rash may be so mild that it goes unnoticed.
In most affected infants and children, Roseola Infantum is caused by infection with a herpesvirus known as human herpesvirus 6 (HHV-6). Less commonly, the condition is thought to result from infection with human herpesvirus 7 (HHV-7). Although the infection is known to spread from person to person, the specific mode of transmission remains unknown.
Roseola Infantum most commonly affects infants and children between the ages of six months and two years. The condition typically occurs during the spring and fall months and, in some cases, has been reported in local outbreaks.
Symptoms of the following disorders can be similar to those of Roseola Infantum. Comparisons may be useful for a differential diagnosis:
Atypical Measles Syndrome (AMS) is most common among adolescents and young adults. This disorder was usually associated with prior immunization using the outdated killed measles vaccines, which are no longer in use. However, inoculation with live measles vaccine has also been known to precede development of AMS. Presumably, inactivated measles virus vaccines do not prevent mild virus infection and can sensitize patients so that disease expression is altered significantly. AMS may begin abruptly, with high fever, headache, abdominal pain, and coughing. The rash may appear one to two days after onset, often beginning on the extremities. Swelling (edema) of the hands and feet may occur. Pneumonia is not uncommon, and nodular dense areas in the lungs may persist for three months or longer.
Measles (Rubeola; Morbilli) is a highly contagious viral disease occurring primarily in children. The disease is characterized by fever, cough, acute nasal membrane discharge (coryza), inflammation of the lining of the eyelids (conjunctivitis), and eruption of small, irregular, bright red spots with a minute bluish or white speck in the center (Koplik's spots) on the inner cheeks or lips and a rash of elevated spots (maculopapular) spreading over the skin. Measles has become rare in the United States since the introduction of Measles vaccines. (For more information, use "Measles" as your search term in the Rare Disease Database.)
Rubella (German Measles) in children is a mild contagious viral disease characterized by swelling of lymph glands and a rash beginning on the face and neck which quickly spreads to the trunk and the extremities. If a woman contracts Rubella during the early months of pregnancy, a spontaneous abortion, stillbirth, or birth defects in the infant may result. (For more information, choose "Rubella" as your search term in the Rare Disease Database.)
Scarlet Fever is an infection caused by bacteria that usually affects the mouth/throat area (pharynx), but may also affect the skin or birth canal. Patients may experience headache, abdominal pain, nausea, and a skin rash. A reddish flush may be apparent on the face, chest and extremities, accompanied by tiny red spots in some cases. The disease is much milder now than in the past, and complications are rare with proper treatment.
Roseola Infantum usually spontaneously resolves within a few days. Therefore, treatment of the condition is primarily symptomatic and supportive. Such measures may include providing certain medications to help reduce fever (antipyretics), such as acetaminophen or ibuprofen. However, aspirin must be avoided, since there appears to be an association between the onset of Reye Syndrome and the use of aspirin in children or adolescents with certain viral illnesses. Reye Syndrome, a rare but potentially life-threatening condition, is primarily characterized by distinctive, fatty changes of the liver and sudden inflammation and swelling of the brain (acute encephalopathy). (For more information on this disorder, please choose "Reye" as your search term in the Rare Disease Database.)
According to reports in the medical literature, if infants or children are prone to experiencing convulsions, the administration of certain sedatives when there is a sudden onset of fever may be helpful in preventing convulsive episodes in association with Roseola Infantum.
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Nelson Textbook of Pediatrics, 15th Ed.: Richard E. Behrman, Editor; W.B. Saunders Company, 1996. Pp. 890-92.
Tohyama M, Hashimoto K, Yasukawa M, Kimura H, Horikawa T, Nakajima K, Urano Y, Matsumoto K, Iijima M, Shear NH. Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome.
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Caselli E, Di Luca D. Molecular biology and clinical associations of Roseoloviruses human herpesvirus 6 and human herpesvirus 7. New Microbiol. 2007 Jul;30(3):173-87.
Dyer JA. Childhood viral exanthems. Pediatr Ann. 2007 Jan;36(1):21-9.
Millichap JG, Millichap JJ. Role of viral infections in the etiology of febrile seizures.
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Identification of Human Herpes Virus-6 as a Causal Agent for Exanthem Subtum. K. Yamanishi et al.; Lancet (May 14 1988; 1(8594)). Pp. 1065-67.
Five Cases of Thrombocytopenia Induced by Primary Human Herpes Virus 6 Infection. T. Yoshikawa et al.; Acta Paediatr Jpn (Jun 1998; 40(3)). Pp. 278-81.
Risk Factors for the Early Acquisition of Human Herpes Virus 6 and Human Virus 7 Infections in Children. B.P. Lanphear et al.; Pediatr Infect Dis J (Sep 1998; 17(9)). Pp. 792-95.
HHV 6,7 AND 8. Recently Discovered Herpes Viruses Explain the Etiology of Well-Known Diseases. T. Bergstrom Lakartidningen (Jun 30 1999; 96(26-27)). Pp. 3161-65.
Human Herpes Virus 6: An Emerging Pathogen. G. Campadelli-Fiume et al.; Emerg Infect Dis (May-Jun 1999; 5(3)). Pp. 353-66.
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Last Updated: 5/15/2009
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