National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Tongue, Hairy is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Related Disorders List
Information on the following diseases can be found in the Related Disorders section of this report:
- Geographic Tongue
Hairy tongue is an uncommon, benign condition that is also known as black hairy tongue or lingua nigra. It is characterized by abnormal elongation and blackish or dark brownish discoloration or "staining" of the thread-like elevations (filiform papillae) that cover most of the tongue's surface (dorsum linguae). Such changes often begin at the back (posterior) region of the top of the tongue and extend toward the front (anterior) of the tongue's surface but never involve the undersurface.
The specific underlying cause of hairy tongue is unknown. However, possible predisposing factors may include poor oral hygiene and overgrowth of pigment-producing bacteria or fungi in the mouth, treatment with certain antibiotic medications, smoking, chewing tobacco, and/or mouthwash use.
Hairy tongue is characterized by elongation and overgrowth (hyperplasia) of the filiform papillae into "hair-like" projections and the development of a dark brown or black coating on the surface of the tongue. Such changes typically occur in a triangular region in front of the circumvallate papillae, which are the largest papillae of the tongue. (These nodular elevations, which typically range from eight to 12 in number, are arranged in the form of a "V".) As noted above, the back region of the top of the tongue may initially be affected with subsequent extension toward the front.
Many individuals with hairy tongue have no associated symptoms (asymptomatic). However, some with the condition may be affected by nausea, gagging, altered taste, bad breath (halitosis), and/or other associated symptoms.
In some cases, hairy tongue may spontaneously disappear. In addition, it typically subsides with appropriate oral hygiene and the elimination of other predisposing factors. (For more information, please see the "Standard Therapies" section below.)
Hairy tongue is thought to result from failure of the normal "shedding" (desquamation) of the outermost layer of the filiform papillae, overgrowth of certain pigment-producing bacteria or fungi normally present in the mouth, and an abnormal accumulation of pigment residues, keratin, or other debris in the region. (Keratin is a fibrous protein that is a primary component of the outermost layer of the skin, nails, and hair.) Although the specific underlying cause of hairy tongue remains unknown, several potential predisposing factors have been implicated. Such factors include treatment with certain antibiotic medications (e.g., tetracycline therapy, which may lead to overgrowth of certain fungi); the use of particular oral bismuth-containing medications; the use of mouthwashes; smoking; chewing tobacco; excessive alcohol consumption; and/or poor oral hygiene. Hairy tongue is not infectious nor does it lead to oral cancer.
In males or females with hairy tongue, the age of onset is variable. Hairy tongue most commonly affects adults; however, it may sometimes occur during childhood or adolescence. It is not an inherited disease.
There are additional disorders and conditions that may result in abnormal color changes or other alterations of the tongue. Such conditions and disorders are typically characterized by symptoms and physical findings that differ from those associated with hairy tongue. (For further information, choose the specific condition name in question as your search term in the Rare Disease Database.)
In individuals with suspected hairy tongue, receiving a thorough evaluation by physicians, dentists, and/or oral surgeons is important to exclude other underlying conditions and to confirm a diagnosis of hairy tongue. Recommended treatment measures typically include removing potential predisposing factors, such as stopping smoking, discontinuing antibiotic therapy if possible and receiving proper alternative treatments as necessary under a physician's direction, and/or other appropriate steps. In addition, affected individuals should speak with their dental specialists for guidance concerning appropriate measures to improve oral hygiene in their particular case. Such measures typically include using a soft-bristled toothbrush to regularly cleanse the tongue.
Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. All studies receiving U.S. government funding, and some supported by private industry, are posted on this government web site.
For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:
Tollfree: (800) 411-1222
TTY: (866) 411-1010
For information about clinical trials sponsored by private sources, contact:
In some individuals with hairy tongue, the administration of certain topical agents (keratolytic agents), such as urea or tretinoin (a derivative of vitamin A), may be recommended to decrease filiform overgrowth by promoting proper "shedding" (desquamation) of the outermost layer of the papillae. Further research is needed to determine the long-term safety and effectiveness of such therapies for hairy tongue.
Beers MH, et al., eds. The Merck Manual. 17th ed. Whitehouse Station, NJ: Merck Research Laboratories; 1999:754.
Fauci AS, et al., eds. Harrison's Principles of Internal Medicine. 14th ed. New York, NY: McGraw-Hill Companies, Inc.; 1998:189-90.
Behrman RE, et al., eds. Nelson Textbook of Pediatrics. 15th ed. Philadelphia, PA: W.B. Saunders Company; 1996:1049, 1889.
Wyngaarden JB, et al., eds. Cecil Textbook of Medicine. 19th ed. Philadelphia, PA: W.B. Saunders Company; 1992:2325.
Heymann WR. Psychotropic agent-induced black hairy tongue. Cutis. 2000;66:25-26.
Mirbod SM, et al. Tobacco-associated lesions of the oral cavity: Part I. Nonmalignant lesions. J Can Dent Assoc. 2000;66:252-56.
Manabe M, et al. Architectural organization of filiform papillae in normal and black hairy tongue epithelium: dissection of differentiation pathways in a complex human epithelium according to their patterns of keratin expression. Arch Dermatol. 1999;135:177-81.
Langtry JA, et al. Topical tretinoin: a new treatment for black hairy tongue (lingua villosa nigra). Clin Exp Dermatol. 1992;17:163-64.
Naidenova M. Some epidemiological and clinical-etiological studies on children with lingua nigra villosa. Stomatologiia (Sofiia). 1989;71:11-15.
Smell and Taste Center
Smell and Taste Center
University of Pennsylvania
5 Ravdin Building
3400 Spruce Street
Philadelphia, PA 19104
NIH/National Institute of Dental and Craniofacial Research
Building 31, Room 2C39
31 Center Drive, MSC 2290
Bethesda, MD 20892
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders, Inc.® (NORD). Cigna members can access the complete report by logging into myCigna.com. For non-Cigna members, a copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html.
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email email@example.com
Last Updated: 5/12/2008
Copyright 1987, 1989, 2001, 2003 National Organization for Rare Disorders, Inc.
Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.