Tularemia

Tularemia

National Organization for Rare Disorders, Inc.

Important

It is possible that the main title of the report Tularemia is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • deerfly fever
  • rabbit fever

Disorder Subdivisions

  • None

General Discussion

Tularemia is a rare but highly infectious disease that resides in small mammals such as rodents and rabbits, and arthropods, such as ticks. The disease is caused by the bacterium Francisella tularensis. Tularemia is most often transmitted to humans by tick or biting fly bite, handling of an infected animal, or inhalation or ingestion of the bacterium. People have not been known to transmit the infection to others. The severity of tularemia varies greatly. Some cases are mild and self-limiting; others may have serious complications, and a small percentage (about 2 percent) are fatal.

Symptoms

The symptoms of tularemia vary greatly among affected individuals. Some individuals may have no apparent symptoms (asymptomatic); others can develop serious complications affecting several organ systems with potentially life-threatening complications. After infection, the period of time it takes symptoms to appear (incubation period) is usually three to five days, but may take as long as two to three weeks.



Most cases of tularemia begin with rapid onset of nonspecific, flu-like symptoms including fever, chills, headaches, muscle pain (myalgia), joint pain (arthralgia), loss of appetite, and a general feeling of ill health (malaise).



Additional symptoms may occur depending upon how a person is infected. Infection through skin (e.g., tick bite or handling of infectious matter) may result in an ulcer or rash on the skin at the point of infection and swollen, painful lymph nodes (lymphadenopathy). These cases may be referred to as ulceroglandular tularemia. In some cases, individuals will have lymphadenopathy without any skin symptoms. These cases are referred to as glandular tularemia. Ulceroglandular and glandular tularemia account for more than 75 percent of cases.



Infection through breathing in (inhalation) the bacterium may result in infection of the lungs (pneumonia), a collection of fluid around the lungs (pleural effusion), and lung abscesses. These cases are referred to as pneumonic tularemia. Eating undercooked, infected animal meat may result in sore throat, nausea, vomiting, diarrhea, and abdominal pain. In rare cases, gastrointestinal bleeding may occur. These cases are referred to as oropharyngeal tularemia.



Tularemia can also affect the eyes resulting in inflammation of the delicate membrane that lines the eyes (conjunctiva), a condition called conjunctivitis. Conjunctivitis can cause pain, redness, and itching of the eyes. Nearby lymph nodes may be swollen and painful. These cases are referred to oculoglandular tularemia.



Some individuals may develop the typhoidal form of tularemia in which fever, myalgias, and general ill health (malaise) develop without accompanying skin lesions or lymphadenopathy. Because of the lack of obvious symptoms, this form of tularemia is difficult to diagnose.



Tularemia has the potential to affect various organ systems of the body including the central nervous system, heart, and liver resulting in inflammation of the membranes surrounding the brain and spinal cord (meningitis), inflammation of the lining of the heart (endocarditis), and inflammation of the liver (hepatitis). Additional serious complications potentially associated with tularemia include infection of the blood (sepsis) and infection of various bones (osteomyelitis).

Causes

Tularemia is caused by the bacterium Francisella tularensis. Most cases occur from being bitten by flies or ticks carrying the disease or from exposure to animals infected with the bacteria.



Tularemia has been found in >100 animal species including rabbits, muskrats, squirrels and beavers. Handling infected animal tissue (e.g., skinning or dressing animal carcasses) or eating insufficiently cooked meat from an infected animal may result in tularemia. Domestic pets such as dogs and cats can be responsible for transmitting tularemia to humans as well. Dogs and cats may come in contact with infected animals or ticks and may spread the disease to humans through their saliva or claws.



Tularemia may be also transmitted through the air by breathing in (inhalation) of aerosolized bacteria. Common activities including cutting brush or mowing lawns can aerosolize the bacteria from the environment and cause infection in humans.



Francisella tularensis is an extremely resilient bacterium and able to survive in the environment (e.g., mud, water, or decaying animal carcasses) for weeks and, rarely, direct contact or ingestion of contaminated materials including water or soil may cause tularemia.



No cases of human-to-human transmission have been documented in the medical literature.



Tularemia has gained more attention in recent years because of its potential for use in biological warfare.

Affected Populations

Tularemia affects males and females, although the majority of cases are males, probably because of greater outdoor exposure opportunities. The disease is rare in the United States with approximately 100-200 new cases reported each year. Some researchers believe that many cases of tularemia often go unreported or misdiagnosed, making it difficult to determine the true frequency of this disease in the general population.



Although tularemia can occur anywhere in the United States, more than half of the cases reported each year occur in rural areas of Arkansas, Missouri, Oklahoma, and Kansas. Tularemia may be found in all parts of Europe and Asia with greater frequency in Siberia and Scandinavian countries.



In Japan, tularemia may be known as yato-byo or Ohara's disease, after Dr. Ohara who first described a rabbit-associated febrile disease.

Standard Therapies

Diagnosis

A diagnosis of tularemia is made by a thorough clinical evaluation, a detailed patient history, and a variety of tests that may include an attempt to isolate the bacteria from blood or body tissue or through specialized blood tests (serologic tests) that measure the body's immune system response against the bacterium.



Treatment

Tularemia is treated with antibiotics. Antibiotics such as doxycycline and Ciprofloxacin can be effective and can be taken by mouth (orally). In severe cases, streptomycin or gentamicin can be given by injection into a muscle or vein.



Other treatment is symptomatic and supportive.

Investigational Therapies

Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. All studies receiving U.S. Government funding, and some supported by private industry, are posted on this government web site.



For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:



Tollfree: (800) 411-1222

TTY: (866) 411-1010

Email: prpl@cc.nih.gov



For information about clinical trials sponsored by private sources, contact:

www.centerwatch.com



For information about clinical trials conducted in Europe, contact:

https://www.clinicaltrialsregister.eu/



Research on infectious diseases such as tularemia is ongoing. For more information about these disorders, contact the World Health Organization (WHO) listed in the Resources section below.

References

TEXTBOOKS

Fauci AS, et al., eds. Harrison's Principles of Internal Medicine, 14th Ed. New York, NY: McGraw-Hill, Inc; 1998:71-4.



Bennett JC, Plum F., eds. Cecil Textbook of Medicine. 20th ed. Philadelphia, PA: W.B. Saunders Co; 1996:1662-4.



Mandell GL, et al., eds. Mandell, Douglas and Bennett's Principles and Practice of Infectious Diseases. 4th ed. New York, NY: Churchill Livingstone Inc; 1995:2060-7.



JOURNAL ARTICLES

Oyston PC, Sjostedt A, Titball RW. Tularemia: bioterrorism defence renews interest in Francisella tularensis. Nat Rev Microbiol. 2004;2:967-78.



Goethert HK, Shani I, Telford SR 3rd. Genotypic diversity of Francisella tularensis infecting Dermacentor variabilis ticks on Martha's Vineyard, Massachusetts. J Clin Microbiol. 2004;42:4968-73.



Tarnvik A, Priebe HS, Grunow R. Tularaemia in Europe: an epidemiological review. Scad J Infect Dis. 2004:36:350-5.



Cronquist SD. Tularemia: the disease and the weapon. Dermatol Clin. 22:313-20.



Conlan JW. Vaccines against Francisella tularensis - past, present and future. Expert Rev Vaccines. 2004;3:307-14.



Avashia SB, et al., First reported prairie dog-to-human tularemia transmission, Texas, 2002. Emerg Infect Dis. 2004;10:483-6.



Gallagher-Smith M, Kim J, Al-Bawardy R, Josko D. Francisella tularensis: possible agent in bioterrorism. Clin Lab Sci. 2004;17:35-9.



Tarnvik A, Berglund L. Tularemia. Eur Respir J. 2003;21:361-73.



Jensen WA, Kirsch CM. Tularemia. Semin Respir Infect. 2003;18:146-58.



Hornick R. Tularemia Revisited. N Engl J Med. 2001;345:1637-9.



Feldman KA, et al., An outbreak of primary pneumonic tularemia on Martha's Vineyard. N Engl J Med. 2001;345:1601-6.



INTERNET

Maurelius, K.Tularemia in Emergency Medicine. Emedicine. April 19, 2011. Available at: http://www.emedicine.com/emerg/topic591.htm Accessed:January 29, 2013.



Centers for Disease Control (CDC) Website. www.cdc.gov/tularemia January 11, 2011. Accessed: January 29, 2013.



Center for Biosecurity. University of Pittsburgh Website. Tularemia Fact Sheet. October 13, 2011. Available at: http://www.upmc-biosecurity.org/website/our_work/biological-threats-and-epidemics/fact_sheets/tularemia.html Accessed:January 29, 2013.



National Institute of Allergy and Infectious Diseases Website. Tularemia. Available at: http://www.niaid.nih.gov/topics/tularemia/Pages/default.aspx Accessed:January 29, 2013.

Resources

Centers for Disease Control and Prevention

1600 Clifton Road NE

Atlanta, GA 30333

Tel: (404)639-3534

Tel: (800)232-4636

TDD: (888)232-6348

Email: cdcinfo@cdc.gov

Internet: http://www.cdc.gov/



NIH/National Institute of Allergy and Infectious Diseases

Office of Communications and Government Relations

6610 Rockledge Drive, MSC 6612

Bethesda, MD 20892-6612

Tel: (301)496-5717

Fax: (301)402-3573

Tel: (866)284-4107

TDD: (800)877-8339

Email: ocpostoffice@niaid.nih.gov

Internet: http://www.niaid.nih.gov/



World Health Organization (WHO)

Avenue Appia 20

Geneva 27, 1211

Switzerland

Tel: 41227912111

Fax: 41227913111

Internet: http://www.who.int/en/



Genetic and Rare Diseases (GARD) Information Center

PO Box 8126

Gaithersburg, MD 20898-8126

Tel: (301)251-4925

Fax: (301)251-4911

Tel: (888)205-2311

TDD: (888)205-3223

Internet: http://rarediseases.info.nih.gov/GARD/



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc.® (NORD). Cigna members can access the complete report by logging into myCigna.com. For non-Cigna members, a copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html.

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