amoxicillin, clarithromycin, and omeprazole

amoxicillin, clarithromycin, and omeprazole

Pronunciation: a MOX i SIL in, kla RITH roe MYE sin, oh MEP ra zole

Brand: Omeclamox-Pak

What is the most important information I should know about amoxicillin, clarithromycin, and omeprazole?

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You should not take this medication if you are allergic to amoxicillin (Amoxil, Augmentin, Moxatag), clarithromycin (Biaxin), omeprazole (Prilosec), or if you have liver disease, or a history of allergic reaction to any antibiotic.

Before you take this medication, tell your doctor if you have kidney disease, myasthenia gravis, or if you are allergic to any drugs.

There are many other drugs that can interact with this medication. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

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While you are taking amoxicillin, clarithromycin, and omeprazole, do not take any of the following medications: ergotamine (Ergomar, Cafergot, Ercaf, Migergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), or pimozide (Orap).

A gout medication called colchicine (Colcrys) can interact with clarithromycin and cause serious or life-threatening medical problems. You should not take colchicine during your treatment with amoxicillin, clarithromycin, and omeprazole, especially if you are an older adult with kidney disease.

What is amoxicillin, clarithromycin, and omeprazole?

Amoxicillin is a penicillin antibiotic. Clarithromycin is a macrolide antibiotic. These antibiotics fight bacteria in the body.

Omeprazole decreases the amount of acid produced in the stomach.

The combination of amoxicillin, clarithromycin, and omeprazole is used to prevent stomach ulcer caused by infection with Helicobacter pylori (H. pylori).

Amoxicillin, clarithromycin, and omeprazole may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking amoxicillin, clarithromycin, and omeprazole?

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You should not take this medication if you are allergic to amoxicillin (Amoxil, Augmentin, Moxatag), clarithromycin (Biaxin), omeprazole (Prilosec), or if you have liver disease, or a history of allergic reaction to any antibiotic.

Taking any of the following medicines together with amoxicillin, clarithromycin, and omeprazole can cause a life-threatening side effect on your heart:

  • ergotamine (Ergomar, Cafergot, Ercaf, Migergot);
  • dihydroergotamine (D.H.E. 45, Migranal Nasal Spray); or
  • pimozide (Orap).

To make sure amoxicillin, clarithromycin, and omeprazole is safe for you, tell your doctor if you have any of these other conditions:

  • kidney disease;
  • myasthenia gravis; or
  • if you are allergic to any drugs.
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FDA pregnancy category C. It is not known whether amoxicillin, clarithromycin, and omeprazole will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

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Omeprazole can pass into breast milk and may harm a nursing baby. Do not breast-feed while taking amoxicillin, clarithromycin, and omeprazole. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.

How should I take amoxicillin, clarithromycin, and omeprazole?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Each dose of this combination medication contains 4 pills (3 capsules and 1 tablet). Take all 4 pills twice daily before you eat, unless your doctor tells you otherwise.

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Do not crush, chew, break, or open the pills. Swallow each pill whole. You may swallow the pills one at a time.

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Take this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Amoxicillin and clarithromycin will not treat a viral infection such as the common cold or flu.

Amoxicillin can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are taking this medication.

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Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking amoxicillin, clarithromycin, and omeprazole?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

What are the possible side effects of amoxicillin, clarithromycin, and omeprazole?

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Get emergency medical help if you have any of these signs of an allergic reaction:

  • hives;
  • wheezing, difficulty breathing;
  • blood in your urine, swelling, rapid weight gain, urinating more or less than usual;
  • fever, swollen glands, rash or itching, joint pain, or general ill feeling;
  • swelling of your face, lips, tongue, or throat; or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
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Call your doctor at once if you have a serious side effect such as:

  • diarrhea that is watery or bloody; or
  • dizziness, fainting, fast or pounding heartbeat.

Less serious side effects may include:

  • headache, weakness;
  • nausea, vomiting, stomach pain, heartburn, gas, indigestion;
  • constipation, mild diarrhea;
  • back pain;
  • cold symptoms such as stuffy nose, sneezing, cough, sore throat; or
  • unusual taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect amoxicillin, clarithromycin, and omeprazole?

A gout medication called colchicine (Colcrys) can interact with clarithromycin and cause serious or life-threatening medical problems. You should not take colchicine during your treatment with amoxicillin, clarithromycin, and omeprazole, especially if you are an older adult with kidney disease.

Many drugs can interact with amoxicillin, clarithromycin, and omeprazole. Below is just a partial list. Tell your doctor if you are using:

  • ampicillin (Omnipen, Principen);
  • carbamazepine (Equetro, Carbatrol, Tegretol);
  • cilostazol (Pletal);
  • digoxin (Lanoxin, Lanoxicaps);
  • ketoconazole (Nizoral);
  • probenecid (Benemid);
  • sildenafil (Viagra, Revatio);
  • tacrolimus (Prograf);
  • theophylline (Elixophyllin, Theo-24, Theochron, Uniphyl);
  • a blood thinner such as warfarin (Coumadin, Jantoven);
  • cholesterol-lowering drugs such as lovastatin (Mevacor, Altoprev, Advicor) or simvastatin (Zocor, Simcor, Vytorin, Juvisync);
  • a heart rhythm medication such as disopyramide (Norpace) or quinidine (Quin-G);
  • HIV/AIDS medications such as atazanavir (Reyataz), nelfinavir (Viracept), or saquinavir (Invirase);
  • iron supplements (Feosol, Mol-Iron, Fergon, Femiron, and others); or
  • a sedative such as alprazolam (Xanax), midazolam (Versed), or triazolam (Halcion).

This list is not complete and there are many other drugs that can interact with amoxicillin, clarithromycin, and omeprazole. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about amoxicillin, clarithromycin, and omeprazole.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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