hydrochlorothiazide and lisinopril

Pronunciation: HYE droe KLOR oh THYE a zide and lye SIN oh pril

Brand: Prinzide, Zestoretic

HCT-Lisinopril 12.5 mg-10 mg-RAN

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HCT-Lisinopril 25 mg-20 mg-GG

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round, peach, imprinted with GP 123

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HCTZ-Lisinopril 12.5 mg-20 mg-TEV

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Lisinopril-HCTZ 10-12.5 mg-WAT

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Lisinopril-HCTZ 20-12.5 mg-EON

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Lisinopril-HCTZ 20-12.5 mg-MYL

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round, yellow, imprinted with M, LH2

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Lisinopril-HCTZ 20-12.5 mg-WAT

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round, blue, imprinted with WATSON 861

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Prinizide 12.5 mg-20 mg

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round, yellow, imprinted with MSD 140, PRINZIDE

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HCT-Lisinopril 25 mg-20 mg-RAN

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round, peach, imprinted with RX 538

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HCTZ-Lisinopril 12.5 mg-10 mg-IVA

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round, blue, imprinted with 10/12.5, Logo 5033

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HCTZ-Lisinopril 25 mg-20 mg-TEV

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round, pink, imprinted with 93, 1037

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Lisinopril-HCTZ 10-12.5 mg-EON

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Lisinopril-HCTZ 10-12.5 mg-MYL

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round, white, imprinted with M, LH1

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Lisinopril-HCTZ 20-12.5 mg-APO

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oval, white, imprinted with 20 12.5, APO

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Lisinopril-HCTZ 20-25 mg-WAT

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round, pink, imprinted with WATSON 862

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Prinizide 12.5 mg-10 mg

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hexagonal, white, imprinted with PRINZIDE, MSD 145

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Zestoretic 20-12.5

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round, white, imprinted with ZESTORETIC, 142

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HCT-Lisinopril 12.5 mg-20 mg-RAN

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round, yellow, imprinted with RX 537

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Lisinopril-HCTZ 10-12.5 mg-APO

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oval, pink, imprinted with 10 12.5, APO

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Lisinopril-HCTZ 20-25 mg-EON

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round, pink, imprinted with E 173

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Prinzide 20-25 mg

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round, yellow, imprinted with PRINZIDE, MSD 142

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Zestoretic 10-12.5

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round, peach, imprinted with ZESTORETIC, 141

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HCTZ-Lisinopril 12.5 mg-10 mg-TEV

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round, peach, imprinted with 93, 1035

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HCTZ-Lisinopril 12.5 mg-20 mg-IVA

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round, yellow, imprinted with 20/12.5, Logo 5034

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HCTZ-Lisinopril 25 mg-20 mg-IVA

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round, pink, imprinted with 20/25, Logo 5032

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Lisinopril-HCTZ 20-25 mg-APO

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oval, pink, imprinted with 20 25, APO

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Lisinopril-HCTZ 20-25 mg-MYL

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round, green, imprinted with M, LH3

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Zestoretic 20-25

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round, peach, imprinted with ZESTORETIC, 145

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What is the most important information I should know about hydrochlorothiazide and lisinopril?

Do not use if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant.

You should not use this medication if you have hereditary angioedema, if you are unable to urinate, if you are allergic to sulfa drugs, or if you have ever had a severe allergic reaction to any ACE inhibitor.

If you have diabetes, do not use hydrochlorothiazide and lisinopril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).

What is hydrochlorothiazide and lisinopril?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Lisinopril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Lisinopril lowers blood pressure and also relieves symptoms of fluid retention.

Hydrochlorothiazide and lisinopril is a combination medicine used to treat hypertension (high blood pressure).

Hydrochlorothiazide and lisinopril may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking hydrochlorothiazide and lisinopril?

You should not use this medication if you are allergic to hydrochlorothiazide or lisinopril, or if you have:

  • hereditary angioedema;
  • if you are unable to urinate;
  • an allergy to sulfa drugs; or
  • if you have ever had a severe allergic reaction to any ACE inhibitor (benazepril, captopril, enalapril, fosinopril, moexipril, perindopril, quinapril, ramipril, trandolapril).

If you have diabetes, do not use hydrochlorothiazide and lisinopril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).

You may also need to avoid taking hydrochlorothiazide and lisinopril with aliskiren if you have kidney disease.

To make sure hydrochlorothiazide and lisinopril is safe for you, tell your doctor if you have:

  • kidney disease (or if you are on dialysis);
  • liver disease;
  • glaucoma;
  • heart disease or congestive heart failure;
  • asthma or allergies;
  • gout;
  • lupus;
  • diabetes; or
  • an allergy to sulfa drugs or penicillin.

FDA pregnancy category D. Do not use if you are pregnant. Stop using and tell your doctor right away if you become pregnant. Hydrochlorothiazide and lisinopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control.

Hydrochlorothiazide and lisinopril can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take hydrochlorothiazide and lisinopril?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take each dose with a full glass of water.

You may have very low blood pressure while taking this medication. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual.

While using hydrochlorothiazide and lisinopril, you may need frequent blood tests at your doctor's office. Your blood pressure will need to be checked often.

If you need surgery or medical tests, tell the doctor ahead of time that you are taking medication that contains hydrochlorothiazide. You may need to stop using the medicine for a short time.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking hydrochlorothiazide and lisinopril?

Drinking alcohol can increase certain side effects of hydrochlorothiazide and lisinopril.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid the regular use of salt substitutes in your diet, and do not take potassium supplements while taking hydrochlorothiazide and lisinopril, unless your doctor has told you to.

What are the possible side effects of hydrochlorothiazide and lisinopril?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • eye pain, vision problems;
  • high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling);
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);
  • dry mouth, nausea, vomiting;
  • feeling weak, drowsy, or restless;
  • a red, blistering, peeling skin rash;
  • psoriasis (raised, silvery flaking of the skin);
  • jaundice (yellowing of the skin or eyes);
  • little or no urinating;
  • swelling, weight gain, feeling short of breath; or
  • fever, chills, body aches, flu symptoms.

Common side effects may include:

  • cough;
  • headache, tired feeling, depressed mood;
  • diarrhea, constipation, upset stomach; or
  • mild skin rash, increased sweating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hydrochlorothiazide and lisinopril?

Other drugs may interact with hydrochlorothiazide and lisinopril, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about hydrochlorothiazide and lisinopril.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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