imipramine

Pronunciation: im IP ra meen

Brand: Tofranil, Tofranil-PM

Imipramine 10 mg-GG

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round, yellow, imprinted with GG, 41

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Imipramine 25 mg-GG

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round, beige, imprinted with 47, GG

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Imipramine Pamoate 100 mg-ROX

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capsule, red/yellow, imprinted with 54758

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Imipramine 10 mg-MUT

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round, yellow, imprinted with MP 4

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Imipramine Pamoate 125 mg-ROX

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capsule, brown, imprinted with 54466

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Imipramine Pamoate 150 mg-ROX

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capsule, brown, imprinted with 54 161

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Tofranil 50 mg-MAL

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round, orange, imprinted with 50, M inside a box

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Imipramine 25 mg-PAR

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round, brown, imprinted with 55, par

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Imipramine 25 mg-URL

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round, brown, imprinted with MP 8

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Imipramine 50 mg-MUT

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round, green, imprinted with MP 79

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Imipramine 10 mg-PAR

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triangular, yellow, imprinted with par, 54

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Imipramine 50 mg-GG

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round, green, imprinted with GG, 42

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Imipramine 50 mg-PAR

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round, green, imprinted with 56, par

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Imipramine Pamoate 75 mg-ROX

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capsule, brown, imprinted with 54591

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Tofranil 25 mg-MAL

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round, orange, imprinted with M inside a box, 25

Image of Tofranil 25 mg-MAL
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Tofranil 10 mg-MAL

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triangular, orange, imprinted with 10, M inside a box

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What is the most important information I should know about imipramine?

You should not take this medicine if you have recently had a heart attack, or if you are being treated with methylene blue injection.

Do not use imipramine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using imipramine. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Do not give this medicine to anyone under 18 years old without the advice of a doctor.

What is imipramine?

Imipramine is a tricyclic antidepressant. Imipramine affects chemicals in the brain that may become unbalanced.

Imipramine is used to treat symptoms of depression. Imipramine is sometimes used to treat bed-wetting in children ages 6 and older.

Imipramine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking imipramine?

You should not use imipramine if you are allergic to it, or:

  • if you have recently had a heart attack;
  • if you are being treated with methylene blue injection; or
  • if you are allergic to other antidepressants (amitriptyline, amoxapine, clomipramine, desipramine, doxepin, nortriptyline, protriptyline, or trimipramine).

Do not use imipramine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

To make sure imipramine is safe for you, tell your doctor if you have:

  • heart disease, a history of heart attack, stroke, or seizures;
  • bipolar disorder (manic-depression), schizophrenia or other mental illness;
  • kidney or liver disease;
  • overactive thyroid, adrenal gland tumor (pheochromocytoma);
  • diabetes (imipramine may raise or lower blood sugar);
  • narrow-angle glaucoma;
  • problems with urination; or
  • if you are being treated with electroconvulsive therapy (ECT).

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using imipramine. Your family or other caregivers should also be alert to changes in your mood or symptoms.

FDA pregnancy category C. It is not known whether imipramine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

Imipramine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Do not give this medicine to anyone under 18 years old without the advice of a doctor. Imipramine is not approved for use in children.

How should I take imipramine?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

If you need surgery, tell the surgeon ahead of time that you are using imipramine. You may need to stop using the medicine for a short time.

It may take up to 3 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

Do not stop using imipramine without first talking to your doctor. You may need to use less and less before you stop the medication completely.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of imipramine can be fatal.

What should I avoid while taking imipramine?

Avoid drinking alcohol. It can cause dangerous side effects when taken together with imipramine.

Grapefruit and grapefruit juice may interact with imipramine and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.

Imipramine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid exposure to sunlight or tanning beds. Imipramine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What are the possible side effects of imipramine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • a light-headed feeling, like you might pass out;
  • new or worsening chest pain, pounding heartbeats or fluttering in your chest;
  • sudden numbness or weakness, problems with vision, speech, or balance;
  • fever, sore throat;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • confusion, hallucinations, unusual thoughts or behavior;
  • painful or difficult urination;
  • seizure (convulsions); or
  • jaundice (yellowing of the skin or eyes).

Serious side effects Side effects may be more likely in older adults.

Common side effects may include:

  • tingly feeling, weakness, lack of coordination;
  • dry mouth, nausea, vomiting, constipation, diarrhea;
  • vision changes, ringing in your ears;
  • breast swelling (in men or women); or
  • decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect imipramine?

Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking imipramine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Before taking imipramine, tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, or sertraline. You must wait at least 5 weeks after stopping fluoxetine (Prozac) before you can take imipramine.

Many drugs can interact with imipramine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with imipramine. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about imipramine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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