isosorbide dinitrate

Pronunciation: EYE soe SOR bide dye NYE trate

Brand: Dilatrate-SR, Isochron, Isordil Titradose

Isordil 40 mg

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round, green, imprinted with WYETH 4192

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Isosorbide 20 mg-GG

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round, green, imprinted with GG 227

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Isosorbide 10 mg-GG

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round, white, imprinted with GG 26

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Isosorbide 10 mg-PAR

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round, white, imprinted with par 021

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Isosorbide Dinitrate 2.5 mg SL-WES

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round, yellow, imprinted with W1

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Isosorbide Dinitrate 5 mg SL-WES

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round, white, imprinted with W3

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Isosorbide 30 mg-PAR

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round, blue, imprinted with par 009

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Isosorbide Dinitrate 10 mg-MAJ

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round, white, imprinted with W W, 771

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Isosorbide Dinitrate 20 mg-WES

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round, green, imprinted with 772, WW, W W

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Isosorbide Dinitrate 20 mg-PAR

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round, green, imprinted with par 022

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Isosorbide Dinitrate 40 mg ER-INW

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round, peach, imprinted with 3613 IL

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Isosorbide Dinitrate 5 mg-GG

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round, pink, imprinted with GG 259

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Isosorbide Dinitrate 5 mg-WES

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round, white, imprinted with West-Ward 769

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What is the most important information I should know about isosorbide dinitrate?

Do not use isosorbide dinitrate if you are taking medicine to treat erectile dysfunction or pulmonary arterial hypertension (PAH). This includes sildenafil (Viagra, Revatio), avanafil (Stendra), tadalafil (Cialis, Adcirca), vardenafil (Levitra, Staxyn), and riociguat (Adempas). Serious, life-threatening side effects may occur.

You should not use isosorbide dinitrate if you have early signs of a heart attack (chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling).

What is isosorbide dinitrate?

Isosorbide dinitrate is in a group of drugs called nitrates. Isosorbide dinitrate dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.

Isosorbide dinitrate is used to treat or prevent attacks of chest pain (angina).

Only the sublingual tablet should be used to treat an angina attack that has already begun.

Isosorbide dinitrate regular and extended-release tablets are used to prevent angina attacks but will not treat an angina attack.

Isosorbide dinitrate may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking isosorbide dinitrate?

Do not use isosorbide dinitrate if you are taking medicine to treat erectile dysfunction or pulmonary arterial hypertension (PAH). This includes sildenafil (Viagra, Revatio), avanafil (Stendra), tadalafil (Cialis, Adcirca), vardenafil (Levitra, Staxyn), and riociguat (Adempas). Serious, life-threatening side effects may occur.

You should not use isosorbide dinitrate if:

  • you are allergic to isosorbide dinitrate, isosorbide mononitrate, or nitroglycerin; or
  • you have early signs of a heart attack (chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating).

To make sure isosorbide dinitrate is safe for you, tell your doctor if you have:

  • congestive heart failure;
  • low blood pressure;
  • kidney disease (or if you are on dialysis);
  • if you take a diuretic or "water pill"; or
  • if you are on a low salt diet.

FDA pregnancy category C. It is not known whether isosorbide dinitrate will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether isosorbide dinitrate passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take isosorbide dinitrate?

Before using isosorbide dinitrate to treat a sudden angina attack, your doctor may want you to first use a nitroglycerin sublingual tablet. Follow your doctor's instructions about what medications to use during an attack and how much time to allow between doses.

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Isosorbide dinitrate is usually taken 2 or 3 times per day. Follow your doctor's dosing instructions very carefully.

If possible, try to rest or stay seated when you take this medicine. Isosorbide dinitrate can cause dizziness or fainting.

Do not crush, chew, break, or open an extended-release capsule or tablet. Swallow it whole.

If you expect to engage in an activity that may cause angina, take the sublingual tablet about 15 minutes before the activity.

If you use the sublingual tablet to treat an angina attack that has already begun, use the medicine at the first sign of chest pain. Place the tablet under your tongue and allow it to dissolve slowly. Do not chew or swallow it.

You may have very low blood pressure while taking this medicine. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. Prolonged illness can lead to a serious electrolyte imbalance, making it dangerous for you to use isosorbide dinitrate.

Seek emergency medical attention if your chest pain gets worse or lasts more than 5 minutes, especially if you have trouble breathing or feel weak, dizzy, or nauseated, or lightheaded.

It is important to keep this medicine on hand at all times in case of an angina attack. Get your prescription refilled before you run out of medicine completely.

You should not stop using isosorbide dinitrate suddenly if you take this medicine to prevent angina. Stopping suddenly may cause you to have a severe attack of angina.

Do not change brands of isosorbide dinitrate without the approval of your doctor.

Store at room temperature, away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Since isosorbide dinitrate is sometimes used only when needed, you may not be on a dosing schedule.

If you are using the medicine regularly, take the missed dose as soon as you remember. If your next dose is less than 2 hours away, skip the missed dose and use the medicine at your next regularly scheduled time.

If you are using the extended-release capsule or tablet and your next dose is less than 6 hours away, skip the missed dose and use the medicine at your next regularly scheduled time.

Do not use extra medicine to make up a missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of isosorbide dinitrate can be fatal.

Overdose symptoms may include a severe throbbing headache, fever, confusion, severe dizziness, fast or pounding heartbeats, vision problems, nausea, vomiting, stomach pain, bloody diarrhea, trouble breathing, sweating, cold or clammy skin, fainting, and seizure (convulsions).

What should I avoid while taking isosorbide dinitrate?

Isosorbide dinitrate can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid drinking alcohol. It can increase some of the side effects of isosorbide dinitrate.

What are the possible side effects of isosorbide dinitrate?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • worsening angina pain;
  • fast or slow heart rate; or
  • pounding heartbeats or fluttering in your chest.

Isosorbide dinitrate can cause severe headaches, especially when you first start using it. These headaches may gradually become less severe as you continue to use isosorbide dinitrate. Do not stop taking this medicine to avoid headaches. Ask your doctor before using any headache pain medication.

Common side effects may be more likely to occur, such as:

  • headache; or
  • flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect isosorbide dinitrate?

Other drugs may interact with isosorbide dinitrate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about isosorbide dinitrate.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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