lamotrigine

lamotrigine

Pronunciation: la MOE tri jeen

Brand: LaMICtal, LaMICtal ODT, LaMICtal ODT Patient Titration Kit (Blue), LaMICtal ODT Patient Titration Kit (Green), LaMICtal ODT Patient Titration Kit (Orange), LaMICtal Starter Kit (Blue), LaMICtal Starter Kit (Green), LaMICtal Starter Kit (Orange), LaMICtal XR, LaMICtal XR Patient Titration Kit (Blue), LaMICtal XR Patient Titration Kit (Green), LaMICtal XR Patient Titration Kit (Orange)

Lamical 25 mg DT

elliptical, white, imprinted with GX CL5

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Lamical 5 mg DT

oblong, white, imprinted with GX CL5

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Lamictal 100 mg

hexagonal, peach, imprinted with LAMICTAL 100

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Lamictal 150 mg

shield, white, imprinted with LAMICTAL 150

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Lamictal 200 mg

hexagonal, blue, imprinted with LAMICTAL 200

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Lamictal 25 mg

shield, white, imprinted with LAMICTAL 25

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Lamotrigine 100 mg-APO

round, peach, imprinted with APO, LAM 100

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Lamotrigine 100 mg-TEV

diamond, pink, imprinted with 9 3, 463

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Lamotrigine 150 mg-APO

round, white, imprinted with APO, LAM 150

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Lamotrigine 150 mg-TEV

diamond, yellow, imprinted with 9 3, 7247

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Lamotrigine 200 mg-APO

round, blue, imprinted with APO, LAM 200

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Lamotrigine 200 mg-TEV

diamond, blue, imprinted with 9 3, 7248

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Lamotrigine 25 mg Chew-TEV

oval, white, cherry, imprinted with 132, 93

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Lamotrigine 25 mg-APO

round, white, imprinted with APO, LAM 25

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Lamotrigine 25 mg-TEV

diamond, white, imprinted with 9 3, 39

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Lamotrigine 5 mg Chew-TEV

round, white, cherry, imprinted with 93, 688

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What is the most important information I should know about lamotrigine?

Before taking lamotrigine, tell your doctor if you have kidney or liver disease, a history of depression or suicidal thoughts, or if you are allergic to other seizure medications.

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Lamotrigine may cause severe or life-threatening skin rash, especially in children and in people who take too high of a dose at the start of treatment with lamotrigine. Serious skin rash may also be more likely to occur if you are taking lamotrigine together with valproic acid (Depakene) or divalproex (Depakote).

Seek emergency medical attention if you have: fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

You may have thoughts about suicide while taking this medication. Your doctor will need to check you at regular visits. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

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Do not stop taking lamotrigine without first talking to your doctor, even if you feel fine. You may have increased seizures if you stop using lamotrigine suddenly.

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Contact your doctor if your seizures get worse or you have them more often while taking lamotrigine.

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Taking this medication during early pregnancy can increase the risk of the baby being born with cleft lip or cleft palate. Tell your doctor if you are pregnant or if you become pregnant during treatment.

What is lamotrigine?

Lamotrigine is an anti-epileptic medication, also called an anticonvulsant.

Lamotrigine is used either alone or in combination with other medications to treat epileptic seizures in adults and children. Lamotrigine is also used to delay mood episodes in adults with bipolar disorder (manic depression).

The immediate-release form of lamotrigine (Lamictal, Lamictal ODT) can be used in children as young as 2 years old when it is given as part of a combination of seizure medications. However, this form should not be used as a single medication in a child or teenager who is younger than 16 years old.

The extended-release form of lamotrigine (Lamictal XR) is for use only in adults and children who are at least 13 years old.

Lamotrigine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking lamotrigine?

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You should not take lamotrigine if you are allergic to it.

To make sure you can safely take lamotrigine, tell your doctor if you have any of these other conditions:

  • kidney or liver disease;
  • a history of depression or suicidal thoughts or actions; or
  • if you are allergic to other seizure medications.

You may have thoughts about suicide while taking this medication. Tell your doctor if you have new or worsening depression or suicidal thoughts during the first several months of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.

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FDA pregnancy category C. It is not known whether lamotrigine will harm an unborn baby. Taking this medication during early pregnancy can increase the risk of the baby being born with cleft lip or cleft palate. Tell your doctor if you are pregnant or plan to become pregnant while taking lamotrigine.

Birth control pills can make lamotrigine less effective, resulting in increased seizures. Tell your doctor if you start or stop using birth control pills while you are taking lamotrigine. Your lamotrigine dose may need to be changed.

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Tell your doctor if you plan to stop taking birth control pills.

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Lamotrigine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take lamotrigine?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Taking too much lamotrigine at the start of treatment may increase your risk of a severe life-threatening skin rash. Follow the directions on your prescription label.

Your doctor may occasionally change your dose over several weeks or months to make sure you get the best results. Take only the amount prescribed by your doctor whenever your dose is changed.

To make sure you are taking the right dose of lamotrigine, your blood may need to be tested often. Visit your doctor regularly.

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Extended-release lamotrigine (Lamictal XR) may be used for different conditions than immediate-release lamotrigine is used for. Always check your refills to make sure you have received the correct size, color, and shape of tablet. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy.

If you are switching to lamotrigine from another anticonvulsant medication, carefully follow your doctor's instructions about timing and dosage when switching from one drug to another.

Do not crush, chew, or break a regular lamotrigine tablet. Swallow it whole.

To take the orally disintegrating tablet (Lamictal ODT), place the tablet on your tongue and move it around in your mouth. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

To take the chewable dispersible tablet, you may either swallow it whole with a glass of water, or chew it first and then swallow it. You may also place the tablet into 1 teaspoon of water or diluted fruit juice and allow it to disperse in the liquid for about 1 minute. Gently swirl the liquid and then swallow all of the mixture right away. Do not save it for later use.

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Do not stop taking lamotrigine without first talking to your doctor, even if you feel fine. You may have increased seizures if you stop using lamotrigine suddenly. You may need to use less and less before you stop the medication completely.

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Wear a medical alert tag or carry an ID card stating that you take lamotrigine. Any medical care provider who treats you should know that you take seizure medication.

Use lamotrigine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

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Store at room temperature away from light and moisture.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include blurred vision, problems with coordination, increased seizures, feeling light-headed, or fainting.

What should I avoid while taking lamotrigine?

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Lamotrigine may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

What are the possible side effects of lamotrigine?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; fever; swollen glands; painful sores in or around your eyes or mouth; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

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Lamotrigine may cause severe or life-threatening skin rash, especially in children and in people who take too high of a dose at the start of treatment with lamotrigine. Serious skin rash may also be more likely to occur if you are taking lamotrigine together with valproic acid (Depakene) or divalproex (Depakote). Seek emergency medical attention if you have a fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

If you have to stop taking lamotrigine because of a serious skin rash, you may not be able to take it again in the future.

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Call your doctor at once if you have any of these other serious side effects:

  • the first sign of any skin rash, no matter how mild;
  • fever, swollen glands, body aches, flu symptoms, headache, neck stiffness, increased sensitivity to light;
  • easy bruising or bleeding, severe tingling, numbness, pain, muscle weakness;
  • upper stomach pain, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes);
  • chest pain, irregular heart rhythm, feeling short of breath;
  • confusion, nausea and vomiting, swelling, rapid weight gain, urinating less than usual or not at all;
  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or
  • increased seizures or worsening of your bipolar disorder.

Less serious side effects may include:

  • tremors, dizziness, tired feeling;
  • blurred vision, double vision;
  • loss of coordination;
  • dry mouth, mild nausea, stomach pain, upset stomach;
  • changes in your menstrual periods;
  • back pain;
  • sleep problems (insomnia); or
  • runny nose, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect lamotrigine?

Tell your doctor about all other medicines you use, especially:

  • hormonal forms of birth control (pills, injections, implants, or skin patches);
  • carbamazepine (Carbatrol, Equetro, Tegretol);
  • divalproex (Depakote);
  • oxcarbazepine (Trileptal);
  • phenobarbital (Solfoton);
  • primidone (Mysoline);
  • phenytoin (Dilantin);
  • rifampin (Rifadin, Rifater, Rifamate, Rimactane); or
  • valproic acid (Depakene, Stavzor).

This list is not complete and other drugs may interact with lamotrigine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about lamotrigine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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