mifepristone (Korlym)

mifepristone (Korlym)

Pronunciation: MIF e PRIS tone

Brand: Korlym

What is the most important information I should know about Korlym?

This medication guide provides information about the Korlym brand of mifepristone. Mifeprex is another brand of mifepristone that is not covered in this medication guide.

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Korlym can harm an unborn baby or cause a miscarriage. Do not use if you are pregnant. You will need to have a negative pregnancy test before you start taking Korlym, or if you restart the medication after not taking it for longer than 2 weeks.

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You should not take Korlym if you are allergic to mifepristone, or if you have unexplained vaginal bleeding, endometrial hyperplasia or a certain type of uterine cancer, if you are pregnant, or if you take steroid medications because of a serious illness or condition (such as an organ transplant).

Before you take Korlym, tell your doctor if you have liver or kidney disease, heart disease, heart failure, coronary artery disease, high blood pressure, endometriosis, a problem with your thyroid or adrenal glands, or an autoimmune disorder.

There are many other drugs that should not be used together with Korlym. Tell your doctor about all other medicines you use.

What is mifepristone (Korlym)?

This medication guide provides information about the Korlym brand of mifepristone. Mifeprex is another brand of mifepristone that is not covered in this medication guide.

Korlym blocks the actions of a hormone called cortisol, which can reduce certain side effects caused by excess cortisol in the body.

Korlym is used to treat high blood sugar (hyperglycemia) in adults with Cushing's syndrome who also have type 2 diabetes or glucose intolerance.

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This medication should not be used to treat type 2 diabetes that is not related to Cushing's syndrome.

Korlym may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking Korlym?

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You should not take Korlym if you are allergic to mifepristone, or if you have:

  • unusual or unexplained vaginal bleeding;
  • endometrial hyperplasia or a certain type of uterine cancer;
  • if you are pregnant; or
  • if you take steroid medications because of a serious illness or condition (such as an organ transplant).

The following drugs should not be used while you are taking Korlym:

  • alfentanil (Alfenta);
  • cyclosporine (Gengraf, Neoral, Sandimmune);
  • digoxin (digitalis, Lanoxin, Lanoxicaps);
  • ergotamine (Ergomar, Cafergot) or dihydroergotamine (D.H.E. 45, Migranal Nasal Spray);
  • fentanyl (Abstral, Actiq, Fentora, Duragesic, Lazanda, Onsolis);
  • pimozide (Orap);
  • quinidine (Quin-G);
  • lovastatin (Mevacor, Altoprev, Advicor) or simvastatin (Zocor, Simcor, Vytorin, Juvisync); or

To make sure you can safely take Korlym, tell your doctor if you have any of these other conditions:

  • liver or kidney disease;

The following drugs should not be used while you are taking Korlym:

  • sirolimus (Rapamune) or tacrolimus (Prograf).

To make sure you can safely take Korlym, tell your doctor if you have any of these other conditions:

  • heart disease, heart failure, coronary artery disease;
  • high blood pressure;
  • endometriosis;
  • a problem with your thyroid or adrenal glands; or
  • an autoimmune disorder such as rheumatoid arthritis, systemic lupus erythematosus (SLE), or psoriasis.
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FDA pregnancy category X. Korlym can harm an unborn baby or cause a miscarriage. Do not use if you are pregnant. Stop taking Korlym and tell your doctor right away if you become pregnant during treatment.

You will need to have a negative pregnancy test before you start taking Korlym, or if you restart the medication after not taking it for longer than 2 weeks.

Korlym can make birth control pills less effective. Use a non-hormone method of birth control (such as a condom with spermicide or diaphragm with spermicide) while you are using this medication and for at least 1 month after your treatment ends.

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It is not known whether Korlym passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Korlym?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

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Korlym is usually taken once per day with a meal. Follow your doctor's instructions.

While using Korlym, you may need blood tests at your doctor's office. Visit your doctor regularly.

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Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Korlym?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of Korlym?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

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Stop using Korlym and call your doctor at once if you have a serious side effect such as:

  • nausea, weakness, tired feeling, feeling like you might pass out;
  • fever, chills, cough with yellow or green mucus;
  • stabbing chest pain, wheezing, feeling short of breath;
  • swelling in your hands or feet;
  • unusual or irregular vaginal bleeding;
  • low blood sugar (headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery); or
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling).

Less serious side effects may include:

  • stomach pain, mild nausea or vomiting;
  • diarrhea or constipation;
  • dry mouth;
  • stuffy nose, sinus congestion, sore throat;
  • headache, dizziness;
  • muscle pain or weakness, joint pain, back pain;
  • decreased appetite; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Korlym?

Many drugs can interact with Korlym. Below is just a partial list. Tell your doctor if you are using:

  • alprazolam (Xanax);
  • boceprevir (Victrelis);
  • bosentan (Tracleer);
  • cimetidine (Tagamet);
  • conivaptan (Vaprisol);
  • fluvastatin (Lescol);
  • imatinib (Gleevec);
  • isoniazid (for treating tuberculosis);
  • levothyroxine (Synthroid, Levothroid);
  • lithium (Eskalith, Lithobid);
  • montelukast (Singulair) or zafirlukast (Accolate);
  • selegiline (Eldepryl, Emsam, Zelapar);
  • St. John's wort;
  • theophylline (Elixophyllin, Theo-24, Theochron, Uniphyl);
  • an antidepressant such as nefazodone, bupropion (Wellbutrin), or fluoxetine (Prozac, Rapiflux, Sarafem, Selfemra, Symbyax);
  • an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifabutin (Mycobutin), rifampin (Rifater, Rifadin, Rifamate), or telithromycin (Ketek);
  • antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), posaconazole (Noxafil), or voriconazole (Vfend);
  • aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;
  • a blood thinner such as warfarin (Coumadin, Jantoven);
  • cancer medication such as paclitaxel (Taxol) or tamoxifen (Soltamox);
  • heart or blood pressure medications such as amiodarone (Cordarone, Pacerone), carvedilol (Coreg), digoxin (digitalis, Lanoxin, Lanoxicaps), disopyramide (Norpace), losartan (Hyzaar, Cozaar), nicardipine (Cardene), procainamide (Procan, Pronestyl), quinidine (Quin-G), or torsemide (Demadex);
  • HIV/AIDS medication such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Atripla, Sustiva), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, Kaletra), saquinavir (Invirase), or telaprevir (Incivek);
  • seizure medications such as carbamazepine (Carbatrol, Equetro, Tegretol), divalproex (Depakote), ethosuximide (Zarontin), fosphenytoin (Cerebyx), phenobarbital (Solfoton), phenytoin (Dilantin), or valproic acid (Depakene, Stavzor);
  • sulfa drugs (Bactrim, Septra, Sulfatrim, SMX-TMP, and others); or
  • type 2 diabetes medications such as glimepiride (Amaryl), glipizide (Glucotrol), nateglinide (Starlix), pioglitazone (Actos, Actoplus Met), repaglinide (Prandin), rosiglitazone (Avandia, Avandamet), or tolbutamide (Orinase).

This list is not complete and there are many other drugs that can interact with Korlym. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

Your doctor or pharmacist can provide more information about Korlym.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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