nateglinide (oral)

Pronunciation: na ta GLYE nide

Brand: Starlix

Starlix 60 mg

slide 1 of 2, Starlix 60 mg,

round, pink, imprinted with STARLIX, 60

Image of Starlix 60 mg
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Starlix 120 mg

slide 2 of 2, Starlix 120 mg,

oblong, yellow, imprinted with STARLIX, 120

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What is the most important information I should know about nateglinide?

You should not use nateglinide if you have type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

What is nateglinide?

Nateglinide is an oral diabetes medicine that helps control blood sugar levels. This medicine helps your body respond better to insulin produced by your pancreas.

Nateglinide is used together with diet and exercise to treat type 2 diabetes. Other diabetes medicines are sometimes used in combination with nateglinide if needed.

Nateglinide may also be used for purposes not listed in this medication guide.

What should I discuss with my doctor before taking nateglinide?

You should not use nateglinide if you are allergic to it, or if you have:

  • type 1 diabetes; or
  • if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

To make sure nateglinide is safe for you, tell your doctor if you have:

  • liver disease; or
  • gout.

It is not known whether nateglinide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

Nateglinide can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

How should I take nateglinide?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Nateglinide is usually taken 3 times daily, within 30 minutes before eating a meal. Follow your doctor's instructions. If you skip a meal, do not take your dose of nateglinide. Wait until your next meal.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, confusion, irritability, dizziness, or feeling shaky. Always keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency.

If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it.

Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor's advice.

Nateglinide is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember, but only if you are getting ready to eat a meal. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

What should I avoid while taking nateglinide?

Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

What are the possible side effects of nateglinide?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • seizure (convulsions); or
  • jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • runny or stuffy nose, sneezing, cough, cold or flu symptoms;
  • diarrhea, nausea;
  • back pain;
  • dizziness; or
  • joint pain or stiffness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect nateglinide?

Many other medicines that can increase or decrease the effects of nateglinide on lowering your blood sugar. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about nateglinide.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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