Hageman Factor Deficiency

National Organization for Rare Disorders, Inc.

Synonyms

  • Factor XII Deficiency
  • HAF Deficiency
  • Hageman Trait

Disorder Subdivisions

  • None

General Discussion

Hageman factor deficiency, also known as factor XII deficiency, is a rare genetic blood disorder that causes prolonged clotting (coagulation) of blood in a test tube without the presence of prolonged clinical bleeding tendencies. It is caused by a deficiency of the Hageman factor (factor XII), a plasma protein (glycoprotein). Although it is thought that factor XII is needed for blood clotting, when it is deficient, other blood clotting factors tend to compensate for its absence. This disorder is thought to be benign and usually presents no symptoms (asymptomatic); it is usually only accidentally discovered through pre-operative blood tests that are required by hospitals. Of substantial recent interest is the role of antibodies to Factor XII in recurrent pregnancy losses.

Resources

National Hemophilia Foundation
116 West 32nd Street, 11th Floor
New York, NY 10001
USA
Tel: (212)328-3700
Fax: (212)328-3777
Tel: (800)424-2634
Email: handi@hemophilia.org
Internet: http://www.hemophilia.org

Canadian Hemophilia Society
400-1255 University Street
Montreal
Quebec, H3B 3B6
Canada
Tel: 514-848-0503
Fax: 514-848-9661
Tel: 800-668-2686
Email: chs@hemophilia.ca
Internet: http://www.hemophilia.ca

NIH/National Heart, Lung and Blood Institute
P.O. Box 30105
Bethesda, MD 20892-0105
Tel: (301)592-8573
Fax: (301)251-1223
Email: nhlbiinfo@rover.nhlbi.nih.gov
Internet: http://www.nhlbi.nih.gov/

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223
Internet: http://rarediseases.info.nih.gov/GARD/

Madisons Foundation
PO Box 241956
Los Angeles, CA 90024
Tel: (310)264-0826
Fax: (310)264-4766
Email: getinfo@madisonsfoundation.org
Internet: http://www.madisonsfoundation.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc.® (NORD). Cigna members can access the complete report by logging into myCigna.com. For non-Cigna members, a copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html.

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  3/11/2008
Copyright  1988, 1989, 2002, 2008 National Organization for Rare Disorders, Inc.


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