Inherited Blood-Clotting Problems

Topic Overview

Some people are born with an increased tendency to form blood clots, which increases their risk for developing blood clots in the legs (deep vein thrombosis) and in the lungs (pulmonary embolism). This tendency is due to inherited blood-clotting irregularities, which are generally related to:

  • Mutated genes (such as factor V Leiden, factor II).
  • Decreased amounts of certain proteins (protein C, protein S, and antithrombin III).
  • Increased levels of other substances (antiphospholipid or lupus anticoagulant).

Many of these blood-clotting irregularities can be identified with special tests. If your doctor suspects that you may have an inherited blood-clotting irregularity, discuss whether testing is needed.

Related Information

References

Other Works Consulted

  • Lipe B, Ornstein DL (2011). Deficiencies of natural anticoagulants, protein C, protein S, and antithrombin. Circulation, 124(14): e365–e368.

Credits

ByHealthwise Staff
Primary Medical ReviewerE. Gregory Thompson, MD - Internal Medicine
Specialist Medical ReviewerJeffrey S. Ginsberg, MD - Hematology
Last RevisedDecember 28, 2011
By: Healthwise StaffLast Revised: December 28, 2011
Medical Review: E. Gregory Thompson, MD - Internal Medicine
Jeffrey S. Ginsberg, MD - Hematology

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