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National Organization for Rare Disorders, Inc.
- Autosomal Dominant Spinocerebellar Degeneration
- Azorean Neurologic Disease
- Machado Disease
- Joseph Disease
- Nigrospinodentatal Degeneration
- Striatonigral Degeneration, Autosomal Dominant Type
- Spinocerebellar Ataxia Type III (SCA 3)
- Machado-Joseph Disease Type I (MJD-I)
- Machado-Joseph Disease Type II (MJD-II)
- Machado-Joseph Disease Type III (MJD-III)
Machado-Joseph Disease (MJD-III), also called spinocerebellar ataxia type III, is a rare, inherited, ataxia (lack of muscular control) affecting the central nervous system and characterized by the slow degeneration of particular areas of the brain called the hindbrain. Patients with MJD may eventually become crippled and/or paralyzed but their intellect remains intact. The onset of symptoms of MJD varies from early teens to late adulthood.
Three forms of Machado-Joseph Disease are recognized: Types MJD-I, MJD-II, and MJD-III. The differences in the types of MJD relate to the age of onset and severity. Earlier onset usually produces more severe symptoms.
WE MOVE (Worldwide Education and Awareness for Movement Disorders)
5731 Mosholu Avenue
Bronx, NY 10471
National Ataxia Foundation
2600 Fernbrook Lane Suite 119
Minneapolis, MN 55447
International Joseph Disease Foundation, Inc.
P.O. Box 994268
Redding, CA 96099
NIH/National Institute of Neurological Disorders and Stroke
P.O. Box 5801
Bethesda, MD 20824
Canadian Association for Familial Ataxias - Claude St-Jean Foundation
3800 Radisson Street
Quebec, Intl H1M 1X6
Tel: (514) 321-8684
MUMS National Parent-to-Parent Network
150 Custer Court
Green Bay, WI 54301-1243
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
PO Box 241956
Los Angeles, CA 90024
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders, Inc.® (NORD). Cigna members can access the complete report by logging into myCigna.com. For non-Cigna members, a copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html.
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email email@example.com
Last Updated: 5/23/2008
Copyright 1986, 1989, 1990, 1993, 1994, 1996, 1997, 2003 National Organization for Rare Disorders, Inc.