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Multiple Endocrine Neoplasia Type 2
National Organization for Rare Disorders, Inc.
- MEN-2 syndrome
- familial medullary thyroid carcinoma (FMTC)
- MEN 2A (Sipple syndrome)
- MEN 2B (multiple neuroma syndrome)
- multiple endocrine neoplasia type 2A
- multiple endocrine neoplasia type 2B
- Wagenmann-Froboese syndrome
Multiple endocrine neoplasia (MEN) type 2 is a rare genetic disorder characterized by an increased risk of developing a specific form of thyroid cancer (medullary thyroid carcinoma) and benign tumors affecting additional glands of the endocrine system. The endocrine system is the network of glands that secrete hormones into the bloodstream where they travel to various areas of the body. These hormones regulate the chemical processes (metabolism) that influence the function of various organs and activities within the body. Hormones are involved in numerous vital processes including regulating heart rate, body temperature and blood pressure. Glands affected in MEN type 2 may secrete excessive amounts of hormones into the bloodstream, which can result in a variety of symptoms.
MEN type 2 is divided into three subtypes: MEN type 2A, MEN type 2B, and familial medullary thyroid carcinoma (FMTC). Medullary thyroid carcinoma (MTC) affects nearly all individuals with MEN type 2 regardless of the subtype. Additional symptoms may occur depending upon the specific subtype present. In FMTC, no other symptoms besides the carcinoma are present. MEN type 2 can run in families or can occur as the result of a spontaneous genetic change (i.e., new mutation) that occurs randomly for no apparent reason.
American Cancer Society, Inc.
1599 Clifton Road NE
Atlanta, GA 30329
NIH/National Institute of Diabetes, Digestive & Kidney Diseases
Office of Communications & Public Liaison
Bldg 31, Rm 9A06
31 Center Drive, MSC 2560
Bethesda, MD 20892-2560
Canadian Multiple Endocrine Neoplasia Society, Inc.
1432 107th Street
North Battleford, S9A 19
Tel: 306 445 8436
Fax: 306 445 8436
8401 Connecticut Avenue
Chevy Chase, MD 20815-5817
ThyCa: Thyroid Cancer Survivors' Association, Inc.
PO Box 1545
New York, NY 10159-1545
Association for Multiple Endocrine Neoplasia Disorders (AMEND)
No. 1 Draper Street
Royal Tunbridge Wells,
Kent, TN4 0PG
Tel: 00 44 1892 516076
Fax: 00 44 1892 516076
NET Patient Foundation
Surrey, GU8 5AH
Tel: 0800 4346476
American Multiple Endocrine Neoplasia Support
1027 Hampshire Drive
Maryville, TN 37801
Pheo Para Troopers
P.O. Box 2064
Kokomo, IN 46904
For a Complete Report
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This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email firstname.lastname@example.org
Last Updated: 1/20/2011
Copyright 2011 National Organization for Rare Disorders, Inc.