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Multiple System Atrophy
National Organization for Rare Disorders, Inc.
- Shy-Drager Syndrome (SDS)
- Sporadic Olivopontocerebellar Atrophy
- Progressive Autonomic Failure with Multiple System Atrophy
- Sporadic OPCA
- Striatonigral Degeneration (SND)
Multiple system atrophy (MSA) is a rare progressive neurological disorder characterized by a varying combination of symptoms. Affected individuals may experience symptoms similar to those found in Parkinson's disease (parkinsonism); cerebellar signs such as progressive impairment of the ability to coordinate voluntary movements (cerebellar ataxia); and impaired functioning of the portion of the nervous system (autonomic nervous system) that regulates certain involuntary body functions (autonomic failure) such as heart rate, blood pressure, sweating, and bowel and bladder control. The exact cause of multiple system atrophy is unknown.
The term multiple system atrophy has generated significant controversy and confusion in the medical literature. The term now encompasses three conditions once thought to be separate disorders, specifically Shy-Drager syndrome, striatonigral degeneration, and sporadic olivopontocerebellar atrophy. Additionally, there is a hereditary form of olivopontocerebellar atrophy that is not part of the multiple system atrophy spectrum.
WE MOVE (Worldwide Education and Awareness for Movement Disorders)
5731 Mosholu Avenue
Bronx, NY 10471
Parkinson's Disease Foundation, Inc.
New York, NY 10018
NIH/National Institute of Neurological Disorders and Stroke
P.O. Box 5801
Bethesda, MD 20824
Vanderbilt's Autonomic Dysfunction Center
Vanderbilt University Medical Center
1211 Medical Center Drive
Nashville, TN 37232-2195
National Dysautonomia Research Foundation
PO Box 301
Red Wing, MN 55066-0102
MUMS National Parent-to-Parent Network
150 Custer Court
Green Bay, WI 54301-1243
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Shy-Drager Syndrome Support Group
8311 Brier Creek Parkway Suite 105-434
Raleigh, NC 27617
Email: Vjames@shy-drager.org or firstname.lastname@example.org
PO Box 241956
Los Angeles, CA 90024
National Parkinson Foundation, Inc.
1501 NW 9th Ave/Bob Hope Road
Miami, FL 33136-1494
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders, Inc.® (NORD). Cigna members can access the complete report by logging into myCigna.com. For non-Cigna members, a copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html.
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email email@example.com
Last Updated: 5/2/2008
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