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|Pronunciation:||FOS a PREP i tan t|
|Brand:||Emend for Injection|
What is the most important information I should know about fosaprepitant?
|You should not receive fosaprepitant if you are taking cisapride (Propulsid) or pimozide (Orap). These drugs may cause life-threatening interactions when taken together with fosaprepitant.|
Before you receive fosaprepitant, tell your doctor if you have liver disease. You may need a dose adjustment or special tests to safely use this medication.
|Fosaprepitant can make birth control pills less effective, resulting in pregnancy. This effect can last for up to 28 days after your last dose of this medication. Talk to your doctor about the use of a non-hormonal back-up form of birth control (such as condoms, a diaphragm, or spermicides) during treatment with fosaprepitant, and for 1 month afterward.|
There are many other medicines that can interact with fosaprepitant. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.
What is fosaprepitant?
Fosaprepitant blocks the actions of chemicals in the body that trigger nausea and vomiting.
Fosaprepitant is used together with other medications to prevent nausea and vomiting that may be caused by cancer chemotherapy.
Fosaprepitant is given ahead of time and will not treat nausea or vomiting that you already have.
Fosaprepitant may also be used for purposes not listed in this medication guide.
What should I discuss with my health care provider before I receive fosaprepitant?
|You should not use this medication if you are allergic to fosaprepitant, aprepitant (oral Emend).|
The following drugs should not be used while you are receiving fosaprepitant:
- cisapride (Propulsid); or
- pimozide (Orap).
To make sure you can safely take fosaprepitant, tell your doctor if you have liver disease.
|Fosaprepitant can make birth control pills less effective, resulting in pregnancy. This effect can last for up to 28 days after your last dose of this medication. Talk to your doctor about the use of a non-hormonal back-up form of birth control (such as condoms, a diaphragm, or spermicides) during treatment with fosaprepitant and for at least 1 month after your treatment ends.|
FDA pregnancy category B. Fosaprepitant is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while you are being treated with fosaprepitant.
|It is not known whether fosaprepitant passes into breast milk or if it could harm a nursing baby. Before you receive this medication, tell your doctor if you are breast-feeding a baby.|
How is fosaprepitant given?
Fosaprepitant is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Fosaprepitant must be given slowly, and the IV infusion can take at least 15 minutes to complete.
The first dose of fosaprepitant is usually given 30 minutes before your chemotherapy treatment begins.
You may also be given other medicines, including oral Emend (aprepitant capsules), for 3 or 4 days to further help prevent nausea and vomiting.
Fosaprepitant is not for long-term use.
What happens if I miss a dose?
Since fosaprepitant injection is given only once on the first day of your chemotherapy treatment, you are not likely to be on a dosing schedule.
What happens if I overdose?
An overdose of this medication is not likely to occur since it is given by a healthcare professional. However, overdose symptoms may include drowsiness and headache.
What should I avoid while receiving fosaprepitant?
Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are being treated with fosaprepitant.
What are the possible side effects of fosaprepitant?
|Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.|
|Tell your caregivers at once if you have any of these serious side effects:|
- feeling light-headed, fainting;
- slow heart rate;
- pale skin, easy bruising or bleeding; or
- pain or burning when you urinate.
Less serious side effects may include:
- nausea, vomiting, heartburn, stomach pain;
- diarrhea or constipation;
- loss of appetite;
- increased thirst or hot, dry skin;
- weakness, dizziness, tired feeling;
- ringing in your ears;
- fever, chills, body aches, flu symptoms;
- sleep problems (insomnia); or
- pain or a hard lump where the medicine was injected.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect fosaprepitant?
Tell your doctor if about all other medicines you use, especially:
- diltiazem (Cardizem, Cartia, Tiazac);
- tolbutamide (Orinase);
- a blood thinner such as warfarin (Coumadin, Jantoven);
- midazolam (Versed) or similar medicines such as Valium, Xanax, or Tranxene;
- an antidepressant such as nefazodone (Serzone) or paroxetine (Paxil);
- an antibiotic such as clarithromycin (Biaxin) or rifampin (Rifater, Rifamate);
- an antifungal medication such as itraconazole (Sporanox), or ketoconazole (Nizoral);
- certain cancer medicines such as etoposide (VePesid), irinotecan (Camptosar), ifosfamide (Ifex), imatinib (Gleevec), paclitaxel (Onxol, Taxol), vinblastine (Velban), or vincristine (Oncovin, Vincasar);
- HIV medicines such as nelfinavir (Viracept), lopinavir/ritonavir (Kaletra), or ritonavir (Norvir);
- seizure medication such as carbamazepine (Tegretol, Carbatrol) or phenytoin (Dilantin); or
- steroid medicine such as dexamethasone (Decadron, Hexadrol) or methylprednisolone (Medapred, Solu-Medrol).
This list is not complete and other drugs may interact with fosaprepitant. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your doctor or pharmacist can provide more information about fosaprepitant.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 2.01. Revision date: 3/10/2011.
Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement. Access the agreement.
- What is the most important information I should know about fosaprepitant?
- What is fosaprepitant?
- What should I discuss with my health care provider before I receive fosaprepitant?
- How is fosaprepitant given?
- What happens if I miss a dose?
- What happens if I overdose?
- What should I avoid while receiving fosaprepitant?
- What are the possible side effects of fosaprepitant?
- What other drugs will affect fosaprepitant?
- Where can I get more information?