Zollinger-Ellison syndrome is a rare condition in which tumors called
gastrinomas form in the pancreas or part of the upper small intestine
(duodenum). The tumors secrete large amounts of a hormone called gastrin.
Gastrin signals the stomach to produce more acid.
At some point during their lives, 90% to 95% of
people with Zollinger-Ellison syndrome develop
peptic ulcers, usually in the upper small intestine
Ulcers that occur in people with this syndrome are
often hard to cure but usually can be controlled with a high dose of a proton
This syndrome is extremely rare, but it may be considered as a cause
when a person has severe or repeated peptic ulcers.
Zollinger-Ellison syndrome may occur at any age,
but the symptoms are more likely to appear between the ages of 30 and
In up to two-thirds of people with this syndrome, the tumors
are cancerous (malignant) and may spread to the lymph nodes and liver.
The main treatment for Zollinger-Ellison syndrome is taking proton pump inhibitors and removing the
tumors causing the overproduction of acid. If
this surgery is successful, you will no longer need to take medicines.
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