This topic provides information about the human papillomavirus (HPV), which causes genital warts and can also cause cervical cancer. If you are looking for information about cervical cell changes or cervical cancer, see:
Human papillomavirus (HPV) is one of the most common sexually transmitted infections (STIs). It is a virus that can be spread through skin-to-skin genital contact. There are many different types of HPV. Some types cause genital warts and are called low-risk. And some types can lead to cervical, anal, or oral cancer and are called high-risk. There is no known cure for HPV, but there is a vaccine that can protect against some types of the virus.
Genital warts are skin growths in the groin, genital, or anal areas. They can be different sizes and shapes. Some look like flat white patches, and others are bumpy, like tiny bunches of cauliflower. Sometimes you can't see the warts at all.
HPV is a virus. Certain types of the virus cause genital warts and some types cause abnormal cervical cell changes and cervical cancer.
HPV and genital warts can be spread through sex or skin-to-skin genital contact with someone who has the virus.
Most people infected with HPV don't have symptoms. But if they do, the symptoms may be so mild that they may not know they are infected. The symptoms may include pain, itching, and bleeding, or you may develop visible genital warts.
If you have symptoms, they will probably occur 2 to 3 months after infection. But you can have symptoms from 3 weeks to many years after infection.
Visible genital warts appear only during active infection. But it is possible to spread the virus even if you can't see the warts.
A doctor can often tell if you have genital warts by looking closely at your genital and anal areas. He or she may ask you questions about your symptoms and your risk factors. Risk factors are things that make you more likely to get an infection.
Sometimes the doctor takes a sample of tissue from the wart for testing.
For women, if you have an abnormal Pap test, your doctor can do an HPV test that looks for high-risk types of the virus.
There is no cure for HPV, but the symptoms can be treated.
Talk to your doctor about whether you should treat visible genital warts. They usually go away with no treatment, but they may also spread. Most people decide to treat them because of the symptoms or because of how the warts look. But if you don't have symptoms and are not worried about how the warts look, you can wait and see if the warts go away.
If you do decide to treat genital warts, talk to your doctor about the best treatment for you. There are prescription medicines that you or your doctor can put on the warts. Or your doctor can remove them with lasers, surgery, or by freezing them off.
Even if you treat visible warts or your warts go away without treatment, the HPV infection can stay in your body's cells. It is possible to spread genital warts to your partner even if you have no signs of them.
The best way to keep from getting genital warts—or any other STI—is to not have sex or any skin-to-skin genital contact. If you do have sex, practice safer sex.
HPV infection is caused by a virus. More than 100 types of HPV have been found. Some types cause genital warts and some can lead to cervical cancer. Types 6 and 11 cause most genital warts. Other types such as 16 and 18 are high-risk and can cause abnormal cell changes on the cervix.
HPV is spread by direct contact.
Infection with the human papillomavirus (HPV) usually does not cause any symptoms and does not always produce visible genital warts. Some types of HPV cause cell changes to the cervix that can cause an abnormal Pap test.
When symptoms do develop, they usually occur 2 to 3 months after infection. But symptoms have been known to occur from 3 weeks to many years after infection.
Symptoms that may occur with genital warts include:
Genital warts can be different sizes and shapes.
Symptoms of genital warts may be similar to those of other conditions.
Based on the type of HPV, you may or may not have visible genital warts.
In women, most precancerous or cancerous cell changes associated with HPV infection occur on the cervix. This is because the cells of the cervix naturally undergo changes in an area called the transformation zone. This process can cause cervical cells to become abnormal when they are infected with HPV.
Infection with high-risk types of HPV increase the chance that a woman with HPV will develop abnormal cervical cell changes. It is important to have regular exams by your doctor. If your doctor finds abnormal cells on a Pap test, the cells can be treated to help prevent them from changing to cancer.
It is not clear whether men who are infected with HPV on the penis are more likely to have precancerous or cancerous changes on the penis than men who are not infected. Because HPV does cause cell changes, more research is being done to find out whether HPV increases the risk of penile cancer. In the United States, cancer of the penis is extremely rare.
The presence of HPV and abnormal cell changes does not affect the outcome of the pregnancy. A pregnant woman who is infected with the type of HPV that causes genital warts may have more complicated warts than a woman who is not pregnant. Genital warts may increase in size, bleed, or become infected with bacteria. Your doctor may recommend treatment. Warts may be passed on to the newborn, but this is rare.
Things that increase a person's risk for getting a sexually transmitted infection, such as HPV and genital warts, include:
If you have a high-risk type of HPV and are using birth control pills for more than 5 years, research suggests that this can increase your risk of getting cervical cancer. footnote 2More research is needed. For more information, see the topic Cervical Cancer.
Call your doctor if:
Call your doctor if you think you've been exposed to a sexually transmitted infection (STI).
Avoid sexual contact until you have been examined by a doctor.
A doctor should check any warts or other symptoms that suggest infection with the human papillomavirus (HPV) or another sexually transmitted infection (STI). Avoid sexual contact until you have been examined. If you have an STI, avoid sexual contact to prevent spreading the virus.
Sometimes warts may go away on their own. If you have genital warts, your doctor may observe your condition without using medical treatment. This is called watchful waiting. This period may vary from several weeks to many months.
A doctor usually can diagnose visible genital warts using your medical history and a physical exam. But not all HPV infections cause visible warts. If you don't have any visible genital warts or other symptoms, it may be hard for your doctor to diagnose HPV infection. Your doctor may ask you the following questions:
After your doctor takes your medical history, you will have a gynecological exam, which usually includes a Pap test.
A Pap test screens for abnormal cells on the cervix. Results of the Pap test may indicate an HPV infection even though you have no visible warts.
Women over age 30 may get a screening test for HPV at the same time as a Pap test. This HPV test looks for the DNA (genetic information) of the virus. Women under 30 usually get the HPV test only if they have an abnormal Pap test.footnote 3
If your doctor finds areas of abnormal tissue on the cervix (which may be related to HPV infection), he or she may recommend treatment.
After the medical history, you will have a physical exam for genital warts.
Doctors do not recommend a screening test for HPV infection in men.
Some experts believe that people who receive anal sex should have a screening for anal cancer, especially if they also have HIV infection. Ask your doctor whether and how often you should be tested.
If visible warts are present, a diagnosis can usually be made without more testing.
When your doctor finds abnormal tissue but cannot make a definite diagnosis, you may have a biopsy for lab tissue studies.
Testing for the type of HPV that is causing warts is not useful for diagnosis. This test is not routinely done for diagnosis or treatment of genital warts.
There is no cure for HPV infection, but warts and cell changes can be treated. HPV infection that causes an abnormal Pap test will be treated differently than the HPV types that cause genital warts.
Genital warts caused by the most common types of human papillomavirus (HPV) may go away on their own without treatment. For this and other reasons, experts sometimes have different approaches to treating genital warts.
Treatments for genital warts include medicines, freezing, laser, or surgery.
The type of medical treatment for genital warts will depend on:
Doctors often recommend medicine applied to warts (topical drug treatment) as the first choice of treatment. A doctor will apply the medicines that have a high risk of causing damage to the skin around the warts. You can apply others at home.
Caution: Do not use nonprescription wart removal products to treat genital warts. These products are not intended to be used in the genital area and may cause serious burning.
Surgery and other treatment
Surgery to remove genital warts may be done when:
Without treatment, external genital warts may remain unchanged, increase in size or number, or go away. Studies show that no one treatment is completely successful. All treatments have advantages and disadvantages. The benefits and effectiveness of each treatment need to be compared with the side effects and cost.
A biopsy of warts that do not go away on their own or after treatment is often done to rule out precancerous or cancerous conditions.
Several choices of treatment for pregnant women have been found to be effective and safe, including trichloroacetic acid (TCA), cryotherapy, and surgery.
You can reduce your risk of becoming infected with the human papillomavirus (HPV) or another sexually transmitted infection (STI). You also can reduce the risk of spreading HPV to your sex partner(s).
Preventing a sexually transmitted infection (STI) is easier than treating an infection after it occurs.
Latex condom use can reduce the risk of becoming infected with HPV. You can reduce the risk of infection if you use a condom every time you have sex. Condoms must be put on before beginning any sexual contact.
Even if you are using another birth control method, you may wish to use condoms to reduce your risk of getting an STI. Female condoms may lower the risk of HPV infection of the cervix, but they do not cover all of the vulva. These condoms are more effective at lowering the risk for other STIs.
If you are age 26 or younger, you can get the HPV shot. The HPV vaccine can protect against genital warts. It is recommended that girls and boys age 11 or 12 get the HPV vaccine, but the vaccine can be given from age 9 to 26. Children ages 9 to 14 years get the vaccine in a series of two shots over 6 months. Children age 15 years and older should get the vaccine as a three-dose series. For the vaccine to work best, all shots in the series must be given.
The HPV vaccine is not useful for treating women who already are infected with HPV.footnote 4 But it may protect a woman against types of the HPV virus other than the one causing her infection.
Home treatments may not cure HPV infection and genital warts. But a doctor may prescribe medicine that you can use at home, such as podofilox lotion or gel or imiquimod cream.
Caution: Do not use nonprescription wart removal products to treat genital warts. These products are not intended for the genital area and may cause serious burning.
You can use at-home care to feel more comfortable.
It is important to remember that most infections are minor, without serious complications. Some cases of HPV infection and genital warts disappear without treatment, although human papillomavirus (HPV) may still be present in your body's cells.
Medicine may be used to destroy bothersome genital warts, relieve your symptoms, and reduce the amount of area affected by warts, particularly when the warts are:
Topical medicine often is the first treatment. For safety, a doctor will apply the topical medicines that could damage the skin around the warts. You can apply other medicines at home. If warts return after one course of treatment with topical medicine, they are treated again only if there are clear reasons for retreatment.
Medicines are not used to treat abnormal cell changes found on a Pap test. For more information on treating abnormal cell changes caused by high-risk HPV, see the topic Abnormal Pap Test.
The following medicines can be applied to the affected area (topical treatment) at home:
Do not use these medicines during pregnancy.
Imiquimod and podofilox are typically the most effective medicine options that can be applied at home. Read the instructions carefully before using these medicines.
Treatment by a doctor can:
Medicines applied by a doctor include:
Treatment for pregnant women includes trichloroacetic acid (TCA), cryotherapy, laser therapy, loop electrosurgical excision procedure (LEEP), and surgical removal by electrocautery or excision.
Avoid sexual contact in the treated area until the area is completely healed.
Some medicine may be more expensive than others.
Warts on the vulva or penis that do not go away on their own or after treatment often are biopsied to rule out precancerous or cancerous conditions.
Removing genital warts does not cure an HPV infection. Warts may go away with topical treatment, but they may return, because HPV may still be in the body's cells.
Even if genital warts have been removed or destroyed:
You may have surgery to remove genital warts if they are widespread and medicine or freezing (cryotherapy) fails to remove them.
If you have a high-risk type of HPV that causes an abnormal Pap test, your doctor may recommend certain types of surgery. For more information about surgical methods to treat abnormal cell changes, see the topic Abnormal Pap Test.
Surgical methods that may be used include:
Surgical choices for pregnant women with genital warts include electrocautery, surgical excision, loop electrosurgical excision (LEEP), and laser surgery.
The success of surgery is related to the number of warts present. The success rate is higher and additional treatments are less likely to be required when surgery is done on fewer and smaller warts. But surgery is less likely to be needed for a few small areas of warts.
Surgery may be more expensive than some other treatment choices.
- Bonnez W (2015). Papillomaviruses. In JE Bennett et al., eds., Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 8th ed., vol. 1, pp. 1794–1806. Philadelphia: Saunders.
- International Collaboration of Epidemiological Studies of Cervical Cancer (2007). Cervical cancer and hormonal contraceptives: Collaborative reanalysis of individual data for 16,573 women with cervical cancer and 35,509 women without cervical cancer from 24 epidemiological studies. Lancet, 370(9599): 1609–1621.
- U.S. Department of Health and Human Services (2007). Human Papillomavirus: HPV information for Clinicians. Available online: http://www.cdc.gov/std/hpv/hpv-clinicians-brochure.htm.
- Hildesheim A, et al. (2007). Effect of human papillomavirus 16/18 L1 viruslike particle vaccine among young women with preexisting infection. JAMA, 298(7): 743–753.
Other Works Consulted
- American Academy of Pediatrics (2015). Human papillomaviruses. In DW Kimberlin et al., eds., Red Book: 2015 Report of the Committee on Infectious Diseases, 30th ed., pp. 578–583. Elk Grove Village, IL: American Academy of Pediatrics.
- Centers for Disease Control and Prevention (2011). Recommendations on the use of quadrivalent human papillomavirus vaccine in males: Advisory Committee on Immunization Practices (ACIP). MMWR, 60(50): 1705–1708. Also available online: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6050a3.htm?s_cid=mm6050a3_e.
- Gillison ML, et al. (2012). Prevalence of oral HPV infection in the United States, 2009–2010. JAMA, 307(7): 693–703.
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