amlodipine and telmisartan

Pronunciation: am LOE de peen and TEL me SAR tan

Brand: Twynsta

What is the most important information I should know about amlodipine and telmisartan?

Do not use this medicine if you are pregnant, and tell your doctor right away if you become pregnant. This medicine can harm an unborn baby.

If you have diabetes, do not use amlodipine and telmisartan together with any medication that contains aliskiren (a blood pressure medicine).

What is amlodipine and telmisartan?

Amlodipine is a calcium channel blocker that relaxes (widens) blood vessels and improves blood flow.

Telmisartan is an angiotensin II receptor antagonist that keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Amlodipine and telmisartan is a combination medicine used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack.

Amlodipine and telmisartan may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking amlodipine and telmisartan?

You should not use this medicine if you are allergic to amlodipine (Norvasc) or telmisartan (Micardis).

If you have diabetes, do not use amlodipine and telmisartan together with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking amlodipine and telmisartan with aliskiren if you have kidney disease.

Tell your doctor if you have ever had:

  • kidney disease (or if you are on dialysis);
  • liver disease;
  • heart disease;
  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or
  • if you are on a low-salt diet.

Do not use if you are pregnant, and tell your doctor right away if you become pregnant. Amlodipine and telmisartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

You should not breast-feed while you are using this medicine.

This medicine is not approved for use by anyone younger than 18 years old.

How should I take amlodipine and telmisartan?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take this medicine with or without food, at the same time each day.

You may have very low blood pressure while taking this medicine. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual.

Your blood pressure will need to be checked often. You may also need frequent blood tests.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Store at room temperature away from moisture and heat. Keep each tablet in the blister pack until you are ready to take one.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking amlodipine and telmisartan?

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Do not use potassium supplements or salt substitutes, unless your doctor has told you to.

What are the possible side effects of amlodipine and telmisartan?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, this medicine can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • shortness of breath (even with mild exertion), swelling, rapid weight gain;
  • new or worsened chest pain;
  • pounding heartbeats or fluttering in your chest;
  • tremors, muscle stiffness or twitching; or
  • high potassium --nausea, slow or unusual heart rate, weakness, loss of movement.

Common side effects may include:

  • swelling in your hands or feet;
  • fast or pounding heartbeats;
  • dizziness, drowsiness;
  • flushing (warmth, redness, or tingly feeling);
  • back pain; or
  • nausea, diarrhea, stomach pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect amlodipine and telmisartan?

Tell your doctor about all your other medicines, especially:

  • digoxin;
  • a diuretic or "water pill";
  • lithium;
  • simvastatin (Zocor, Vytorin);
  • medicine to prevent organ transplant rejection --cyclosporine, tacrolimus;
  • an ACE inhibitor --benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril; or
  • NSAIDs (nonsteroidal anti-inflammatory drugs) --aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may affect amlodipine and telmisartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about amlodipine and telmisartan.

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