amoxicillin, omeprazole, and rifabutin

What is the most important information I should know about amoxicillin, omeprazole, and rifabutin?

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

What is amoxicillin, omeprazole, and rifabutin?

Amoxicillin is a penicillin antibiotic. Omeprazole is a proton pump inhibitor that decreases stomach acid. Rifabutin is an antibiotic that fights bacteria.

Amoxicillin, omeprazole, and rifabutin is a combination medicine that is used to treat Helicobacter pylori (H. pylori) infection in adults.

Amoxicillin, omeprazole, and rifabutin may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking amoxicillin, omeprazole, and rifabutin?

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with amoxicillin, omeprazole, and rifabutin. Your doctor may change your treatment plan if you also use:

• delavirdine;
• rilpivirine (Juluca); or
• voriconazole.

Tell your doctor if you have ever had:

• an allergic reaction to an antibiotic medicine;
• lupus;
• liver disease;
• kidney disease; or
• mononucleosis.

This medicine may affect fertility (ability to have children) in men.

How should I take amoxicillin, omeprazole, and rifabutin?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

For up to 14 days after you last took amoxicillin, omeprazole, and rifabutin, this medicine can affect the results of certain medical tests, including a drug-screening urine test. You may have false results. Tell the laboratory staff that you use amoxicillin, omeprazole, and rifabutin. Tell any doctor who treats you that you are using amoxicillin, omeprazole, and rifabutin.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Amoxicillin, omeprazole, and rifabutin will not treat a viral infection such as the flu or a common cold.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Overdose symptoms include drowsiness, confusion, blurred vision, nausea, vomiting, dry mouth, sweating, or fast heartbeats.

What should I avoid while taking amoxicillin, omeprazole, and rifabutin?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Avoid wearing soft contact lenses. The rifabutin in this medicine can discolor your tears and could permanently stain contact lenses.

What are the possible side effects of amoxicillin, omeprazole, and rifabutin?

• severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
• a light-headed feeling, like you might pass out;
• easy bruising, unusual bleeding, purple or red spots under your skin;
• eye pain or redness, vision problems, seeing spots, your eyes may be more sensitive to light;
• flu-like symptoms --fever, chills, sweating, tiredness, body aches, vomiting, chest pain, cough, feeling short of breath;
• kidney problems --urinating more or less than usual, fever, nausea, vomiting, blood in your urine, confusion, swelling, rapid weight gain; or
• lupus-like symptoms --muscle or joint pain, flu symptoms, chest pain, and a rash or patchy skin color that worsens in sunlight.

Common side effects may include:

• red, orange, or brown discoloration of your skin, tears, sweat, saliva, urine, or stools;
• indigestion, stomach pain, nausea, vomiting, diarrhea;
• headache;
• discolored urine;
• sore throat;
• rash; or
• vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect amoxicillin, omeprazole, and rifabutin?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect the blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines. Many drugs can affect amoxicillin, omeprazole, and rifabutin, especially:

• allopurinol;
• clopidogrel;
• digoxin;
• methotrexate;
• St. John's wort;
• tacrolimus;
• an antibiotic --clarithromycin, rifampin, telithromycin;
• antifungal medicine --fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole;
• antiviral medicine to treat HIV/AIDS --fosamprenavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, tipranavir; or
• a blood thinner --warfarin, Coumadin, Jantoven.

This list is not complete and many other drugs may affect amoxicillin, omeprazole, and rifabutin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about amoxicillin, omeprazole, and rifabutin.