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daratumumab and hyaluronidase

daratumumab and hyaluronidase

Pronunciation: DAR a TOOM ue mab and HYE al ure ON i dase o

Brand: Darzalex Faspro

What is the most important information I should know about daratumumab and hyaluronidase?

This medicine may harm an unborn baby. Use effective birth control to prevent pregnancy while using daratumumab and hyaluronidase and for at least 3 months after your last dose.

Carefully follow all instructions about the use of birth control while you are using daratumumab and hyaluronidase in combination with other medicines.

What is daratumumab and hyaluronidase?

Daratumumab and hyaluronidase is used to treat multiple myeloma in adults.

Daratumumab and hyaluronidase is sometimes used in combination with other medicines.

Daratumumab and hyaluronidase may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using daratumumab and hyaluronidase?

You should not use this medicine if you are allergic to daratumumab or hyaluronidase.

Tell your doctor if you have ever had:

  • breathing problems;
  • hepatitis B; or
  • herpes zoster (shingles).

Daratumumab and hyaluronidase may harm an unborn baby. Use effective birth control to prevent pregnancy while using this medicine and for at least 3 months after your last dose. Tell your doctor if you become pregnant.

Daratumumab and hyaluronidase is sometimes used in combination with lenalidomide. Both men and women using lenalidomide must use effective birth control. Even one dose can cause severe, life-threatening birth defects or death of a baby if the mother or the father is taking lenalidomide at the time of conception or during pregnancy.

Carefully follow all instructions about the use of birth control while you are using daratumumab and hyaluronidase in combination with other medicines.

How is daratumumab and hyaluronidase given?

Daratumumab and hyaluronidase is injected under the skin. A healthcare provider will give you this injection over a period of 3 to 5 minutes.

You may be given other medications to help prevent serious side effects or an allergic reaction. Keep using these medicines for as long as your doctor has prescribed.

Daratumumab and hyaluronidase is usually given every 1 to 4 weeks until your body no longer responds to the medicine. Your doctor will determine how long to treat you with this medicine, and how often you will receive an injection.

The injection is given under the skin of your stomach. Do not given any other injections (such as insulin) into the same place where your last daratumumab and hyaluronidase injection was given.

When used in combination with other medicines, the dosing schedules of the other medicines may be different from your daratumumab and hyaluronidase schedule.

You will need frequent medical tests, and your next dose may be delayed based on the results.

Daratumumab and hyaluronidase can have long lasting effects on your body, and can affect the results of certain medical tests for up to 6 months after your last dose. Make sure any doctor caring for you knows you were treated with this medicine.

If you've ever had hepatitis B, using daratumumab and hyaluronidase can cause this virus to become active or get worse. You may need frequent liver function tests while using this medicine and for several months after you stop.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your daratumumab and hyaluronidase injection.

Try not to miss any doses of any other medicines you use in combination with daratumumab and hyaluronidase.

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while using daratumumab and hyaluronidase?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of daratumumab and hyaluronidase?

Get emergency medical help if you have signs of an allergic reaction: itching, hives; runny or stuffy nose, fever, chills, headache, nausea, vomiting; throat irritation, cough, chest pain, fast heartbeats, wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • easy bruising, unusual bleeding, purple or red spots under your skin;
  • right-sided upper stomach pain, vomiting, loss of appetite, yellowing of your skin or eyes, and not feeling well;
  • low white blood cell counts --fever, mouth sores, skin sores, sore throat, cough, trouble breathing; or
  • a lung infection --fever, chills, cough with mucus, chest pain, feeling short of breath.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • itching, swelling, bruising, or redness where the medicine was injected;
  • nausea, vomiting, diarrhea, constipation;
  • fever, low blood cell counts;
  • trouble breathing, lung infection;
  • numbness, tingling, or burning pain in your hands or feet;
  • feeling tired;
  • cold symptoms such as stuffy nose, sneezing, sore throat;
  • muscle spasm, back pain; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect daratumumab and hyaluronidase?

Other drugs may affect daratumumab and hyaluronidase, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about daratumumab and hyaluronidase.

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