deferiprone

What is the most important information I should know about deferiprone?

What is deferiprone?

Deferiprone binds to iron and removes it from the bloodstream.

Deferiprone is used to treat iron overload caused by blood transfusions in people with certain hereditary red blood cell disorders (thalassemia syndrome).

Deferiprone may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking deferiprone?

Tell your doctor if you have ever had:

• liver disease; or
• a weak immune system.

• If you are a woman, you may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
• If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
• Tell your doctor right away if a pregnancy occurs while either the mother or the father is using deferiprone.

How should I take deferiprone?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Deferiprone is usually taken 3 times per day. Take the first daily dose each morning, the second dose at mid-day, and the third dose in the evening.

Measure liquid medicine (oral solution) carefully. Use only the dose-measuring cup provided with the oral solution. Drink all of the medicine in the measuring cup. Then add about 1 tablespoon of water to the cup, swirl gently and drink. Hand-wash the measuring cup after each use.

You will need frequent medical tests, and your next dose may be delayed based on the results.

Deferiprone doses are based on weight. Your dose needs may change if you gain or lose weight.

Throw away any liquid medicine not used within 35 days after you first opened the bottle.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

What should I avoid while taking deferiprone?

What are the possible side effects of deferiprone?

• fever, chills, body aches;
• flu symptoms;
• skin sores; or
• sores in your mouth and throat.

Further doses may be delayed until your infection clears up.

Deferiprone may cause your urine to turn a reddish-brown color. This side effect is usually not harmful. Call your doctor if you also have upper stomach pain, clay-colored stools, or jaundice (yellowing of your skin or the whites of your eyes).

Common side effects may include:

• nausea, vomiting, stomach pain;
• infections;
• joint pain; or
• abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect deferiprone?

If you take any of the following medicines, take your deferiprone dose 4 hours before or 4 hours after you take the other medicine:

• an antiacid that contains aluminum;
• a medicine or supplement that contains iron (including ferric citrate, Feosol, Fergon, Ferrocite, Hemocyte, and others; or
• vitamin or mineral supplements that contain iron or zinc.

Avoid taking an herbal supplement containing milk thistle.

Other drugs may affect deferiprone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about deferiprone.