How is defibrotide given?
Defibrotide is injected into a vein through an IV. This medicine must be given slowly, and the IV infusion can last at least 2 hours.
You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.
Defibrotide is usually given for at least 21 days, to a maximum of 60 days if symptoms have not fully improved.
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Defibrotide must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.
Do not mix defibrotide with other medicines in the same IV line. Follow your doctor's instructions about flushing your IV line after each injection.
Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.
After mixing defibrotide with a diluent, store in the refrigerator and use within 24 hours.
Mixed medicine must be used within 4 hours if you keep it at room temperature.
Each single-use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.