What is the most important information I should know about docetaxel?

Docetaxel can cause severe side effects including death, especially if you receive high doses, if you have liver disease, or if you have non-small cell lung cancer and you have been treated in the past with chemotherapy that contains platinum (cisplatin, carboplatin, oxaliplatin).

Docetaxel can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.

What is docetaxel?

Docetaxel is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Docetaxel is used to treat breast cancer, lung cancer, prostate cancer, stomach cancer, and head/neck cancer.

Docetaxel may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving docetaxel?

Tell your doctor about your complete health history and all medications you have used. Docetaxel can cause severe side effects including death, especially:

• if you receive high doses;
• if you have liver disease; or
• if you have non-small cell lung cancer and you have been treated in the past with chemotherapy that contains platinum (cisplatin, carboplatin, oxaliplatin).

To make sure docetaxel is safe for you, tell your doctor if you have ever had:

• liver disease or alcoholism;
• heart disease;
• fluid retention; or
• if you need to limit your alcohol intake.

Using docetaxel may increase your risk of developing other types of cancer, such as leukemia. Ask your doctor about your specific risk.

How is docetaxel given?

Docetaxel is injected into a vein through an IV, usually once every 3 weeks. A healthcare provider will give you this injection. You may receive other cancer medicines at the same time.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when docetaxel is injected.

Docetaxel can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.

You may need to have your vision checked if you have any vision problems while receiving docetaxel.

What happens if I miss a dose?

What happens if I overdose?

What should I avoid while receiving docetaxel?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

This medicine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

What are the possible side effects of docetaxel?

• sudden vision problems;
• redness, swelling, warmth, or skin changes where the injection was given;
• extreme weakness, severe vomiting or diarrhea;
• redness or peeling of the skin on your hands and feet;
• numbness, burning, or tingling in your hands or feet;
• a feeling of being drunk --confusion, stumbling, extreme drowsiness;
• low blood cell counts --fever, chills, tiredness, flu-like symptoms, cough, mouth sores, skin sores, pale skin, cold hands and feet, feeling light-headed or short of breath;
• low platelets in your blood --easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
• fluid retention --little or no urinating, swelling of your ankles or feet, rapid weight gain; or
• liver problems --upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Older adults may be more likely to have side effects from this medicine.

Common side effects may include:

• feeling weak, tired, or short of breath;
• mouth sores, altered sense of taste;
• swelling;
• nausea, vomiting, loss of appetite;
• constipation, diarrhea;
• hair loss (may be permanent in some cases);
• muscle or joint pain;
• rash; or
• fingernail or toenail changes.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect docetaxel?

Other drugs may interact with docetaxel, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your doctor or pharmacist can provide more information about docetaxel.