Pronunciation: du LOX e teen
Brand: Cymbalta, Drizalma Sprinkle, Irenka
20 mg, capsule, green, imprinted with 20 mg, LILLY 3235
30 mg, capsule, blue/white, imprinted with Lilly 3240, 30 mg
20 mg, capsule, green, imprinted with TEVA, 7542
30 mg, capsule, blue/white, imprinted with TEVA, 7543
60 mg, capsule, blue/green, imprinted with TEVA, 7544
20 mg, capsule, blue, imprinted with 2890
30 mg, capsule, blue/gray, imprinted with LOGO 2891
20 mg, capsule, green, imprinted with X, 01
30 mg, capsule, blue/white, imprinted with X, 02
60 mg, capsule, blue/green, imprinted with X 03
20 mg, capsule, yellow, imprinted with B, 746
30 mg, capsule, green/white, imprinted with B, 747
60 mg, capsule, brown/green, imprinted with B, 748
20 mg, capsule, green, imprinted with 20 mg, LILLY 3235
30 mg, capsule, blue/white, imprinted with Lilly 3240, 30 mg
60 mg, capsule, blue/yellow, imprinted with Lilly 3237, 60 mg
30 mg, capsule, blue/white, imprinted with X, 02
20 mg, capsule, clear/green, imprinted with LOGO, 007
20 mg, capsule, green, imprinted with H, 190
20 mg, capsule, white, imprinted with 557, 20mg
30 mg, capsule, blue/white, imprinted with H, 191
30 mg, capsule, green/white, imprinted with 558, 30mg
30 mg, capsule, clear/white, imprinted with LOGO, 008
40 mg, capsule, white, imprinted with LU, H25
60 mg, capsule, gray/white, imprinted with LOGO 2892
60 mg, capsule, blue/clear, imprinted with LOGO, 009
60 mg, capsule, blue/green, imprinted with H, 192
60 mg, capsule, blue/white, imprinted with 559, 60mg
20 mg, capsule, green/white, imprinted with 241, 20 mg
30 mg, capsule, blue/green, imprinted with 242, 30 mg
60 mg, capsule, blue/white, imprinted with 243, 60 mg
People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Tell your doctor right away if you have any sudden changes in mood or behavior, or thoughts about suicide.
Do not stop using duloxetine without first asking your doctor.
Duloxetine is a serotonin and norepinephrine reuptake inhibitor antidepressant (SNRI).
Duloxetine is used to treat major depressive disorder in adults. Duloxetine is also used to treat general anxiety disorder in adults and children at least 7 years old.
Duloxetine is also used in adults to treat diabetic nerve pain or chronic muscle or joint pain (such as low back pain and osteoarthritis pain).
Some brands of duloxetine are also used to treat fibromyalgia (a chronic pain disorder). Drizalma is for treating fibromyalgia only in adults. Cymbalta may be used to treat fibromyalgia in adults and children at least 13 years old.
Duloxetine may also be used for purposes not listed in this medication guide.
You should not use duloxetine if you are allergic to it.
Do not take duloxetine within 5 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine. A dangerous drug interaction could occur.
Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with duloxetine could cause a serious condition called serotonin syndrome.
Not approved for use by anyone younger than 7 years old.
Tell your doctor if you have ever had:
People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.
Taking this medicine during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop duloxetine without asking your doctor.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of duloxetine on the baby.
If you are breastfeeding, tell your doctor if you notice drowsiness, feeding problems, and slow weight gain in the nursing baby.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Taking duloxetine in higher doses or more often than prescribed will not make it more effective, and may increase side effects.
Swallow the capsule whole and do not crush, chew, break, or open it.
Take with or without food.
Your blood pressure will need to be checked often.
Tell your doctor if you have any changes in sexual function, such as loss of interest in sex, trouble having an orgasm, or (in men) problems with erections or ejaculation. Some sexual problems can be treated.
Your symptoms may not improve for up to 4 weeks.
Do not stop using duloxetine suddenly, or you could have unpleasant symptoms (such as agitation, confusion, tingling or electric shock feelings). Ask your doctor before stopping the medicine.
Store at room temperature away from moisture and heat.
Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen, naproxen, Advil, Aleve, Motrin, and others. Using an NSAID with duloxetine may cause you to bruise or bleed easily.
Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Drinking alcohol may increase your risk of liver damage, especially if you take Drizalma.
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Tell your doctor right away if you have new or sudden changes in mood or behavior, including new or worse depression or anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, more active or talkative, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Many drugs can affect duloxetine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all other medicines you use.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2022 Cerner Multum, Inc. Version: 17.01. Revision date: 11/1/2021.
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