Naproxen can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Naproxen may also cause stomach or intestinal bleeding, which can be fatal.
Esomeprazole can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine.
Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it.
Esomeprazole may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight.
You may be more likely to have a broken bone while taking this medicine long term or more than once per day.
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Esomeprazole is a proton pump inhibitor.
Esomeprazole and naproxen is a combination medicine used to treat symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The esomeprazole in this medicine helps reduce the risk of stomach ulcers in people who may be at risk for them while receiving treatment with an NSAID.
Esomeprazole and naproxen may also be used for purposes not listed in this medication guide.
Naproxen can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Naproxen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using naproxen, especially in older adults.
You should not use this medicine if you are allergic to esomeprazole (Nexium) or naproxen (Aleve, Naprosyn), or if:
Tell your doctor if you have ever had:
You may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy.
If you are pregnant, you should not take naproxen unless your doctor tells you to. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
Esomeprazole and naproxen is not approved for use by anyone younger than 12 years old or weighing less than 38 kilograms (84 pounds).
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take the medicine at least 30 minutes before a meal. Use the lowest dose that is effective in treating your condition.
Swallow the tablet whole and do not crush, chew, or break it.
Esomeprazole and naproxen can affect the results of certain medical tests. Tell any doctor who treats you that you are using this medicine.
Store at room temperature away from moisture, heat, and light.
This medicine can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.
Avoid drinking alcohol. It may increase your risk of stomach bleeding.
Taking regular naproxen together with esomeprazole (Nexium) will not work the same way as taking combination esomeprazole and naproxen (Vimovo). Do not substitute this medicine with over-the-counter products.
Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to naproxen (such as aspirin, ibuprofen, or ketoprofen).
Get emergency medical help if you have signs of an allergic reaction (hives, sneezing, runny or stuffy nose, wheezing, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Stop taking this medicine and get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.
Call your doctor at once if you have:
Taking esomeprazole and naproxen long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk.
If you use esomeprazole and naproxen for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Ask your doctor before using esomeprazole and naproxen if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily.
Tell your doctor about all your current medicines. Many drugs can affect esomeprazole and naproxen, especially:
This list is not complete and many other drugs may affect esomeprazole and naproxen. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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