Home
Individuals and Families
Health and Wellness
Wellness Library
hydrochlorothiazide and irbesartan

hydrochlorothiazide and irbesartan

Pronunciation: HYE droe KLOR oh THYE a zide and ir be SAR tan

Brand: Avalide

Hydrochlorothiazide-Irbesartan

slide 1 of 11, Hydrochlorothiazide-Irbesartan,

12.5 mg-150 mg, round, red, imprinted with 54 857

Image of Hydrochlorothiazide-Irbesartan
slide 1 of 11

Hydrochlorothiazide-Irbesartan

slide 2 of 11, Hydrochlorothiazide-Irbesartan,

12.5 mg-300 mg, oval, yellow, imprinted with 54 948

Image of Hydrochlorothiazide-Irbesartan
slide 2 of 11

Hydrochlorothiazide-Irbesartan

slide 3 of 11, Hydrochlorothiazide-Irbesartan,

12.5 mg-300 mg, capsule, pink, imprinted with TEVA, 7239

Image of Hydrochlorothiazide-Irbesartan
slide 3 of 11

Hydrochlorothiazide-Irbesartan

slide 4 of 11, Hydrochlorothiazide-Irbesartan,

12.5 mg-150 mg, capsule, pink, imprinted with TEVA, 7238

Image of Hydrochlorothiazide-Irbesartan
slide 4 of 11

Hydrochlorothiazide-Irbesartan

slide 5 of 11, Hydrochlorothiazide-Irbesartan,

12.5 mg-150 mg, oval, orange, imprinted with ML 34

Image of Hydrochlorothiazide-Irbesartan
slide 5 of 11

Hydrochlorothiazide-Irbesartan

slide 6 of 11, Hydrochlorothiazide-Irbesartan,

12.5 mg-300 mg, oval, orange, imprinted with ML33

Image of Hydrochlorothiazide-Irbesartan
slide 6 of 11

Hydrochlorothiazide-Irbesartan

slide 7 of 11, Hydrochlorothiazide-Irbesartan,

12.5 mg-300 mg, capsule, pink, imprinted with TEVA, 7239

Image of Hydrochlorothiazide-Irbesartan
slide 7 of 11

Hydrochlorothiazide-Irbesartan

slide 8 of 11, Hydrochlorothiazide-Irbesartan,

12.5 mg-150 mg, capsule, pink, imprinted with 325, HH

Image of Hydrochlorothiazide-Irbesartan
slide 8 of 11

Hydrochlorothiazide-Irbesartan

slide 9 of 11, Hydrochlorothiazide-Irbesartan,

12.5 mg-300 mg, capsule, pink, imprinted with 327, HH

Image of Hydrochlorothiazide-Irbesartan
slide 9 of 11

Avalide

slide 10 of 11, Avalide,

12.5 mg-150 mg, oblong, peach, imprinted with 2775, LOGO HEART

Image of Avalide
slide 10 of 11

Avalide

slide 11 of 11, Avalide,

12.5 mg-300 mg, oblong, peach, imprinted with 2776, LOGO HEART

Image of Avalide
slide 11 of 11

What is the most important information I should know about hydrochlorothiazide and irbesartan?

You should not use this medicine if you are unable to urinate, or if you are allergic to sulfa drugs.

Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant.

If you have diabetes, do not use hydrochlorothiazide and irbesartan together with any medication that contains aliskiren (a blood pressure medicine).

What is hydrochlorothiazide and irbesartan?

Hydrochlorothiazide is a diuretic (water pill). Irbesartan is an angiotensin II receptor blocker (sometimes called an ARB blocker).

Hydrochlorothiazide and irbesartan is a combination medicine used to treat high blood pressure (hypertension).

Hydrochlorothiazide and irbesartan may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking hydrochlorothiazide and irbesartan?

You should not use this medicine if you are allergic to irbesartan or hydrochlorothiazide, or:

  • if you are unable to urinate; or
  • if you are allergic to sulfa drugs.

If you have diabetes, do not use hydrochlorothiazide and irbesartan together with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking hydrochlorothiazide and irbesartan with aliskiren if you have kidney disease.

Tell your doctor if you have ever had:

  • liver disease;
  • congestive heart failure;
  • glaucoma;
  • low or high levels of potassium in your blood;
  • asthma or allergies;
  • high cholesterol or triglyceride levels;
  • gout;
  • lupus;
  • diabetes; or
  • an allergy to penicillin.

Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Irbesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

You should not breastfeed while using this medicine.

How should I take hydrochlorothiazide and irbesartan?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take this medicine with or without food.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance.

Your blood pressure will need to be checked often. Your blood and urine may also be tested if you have been vomiting or are dehydrated.

If you need surgery or medical tests, tell the surgeon ahead of time that you are using hydrochlorothiazide and irbesartan.

It may take up to 4 weeks for this medication to control your blood pressure. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include fast or slow heartbeat, feeling light-headed, or fainting.

What should I avoid while taking hydrochlorothiazide and irbesartan?

Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis.

Drinking alcohol can further lower your blood pressure and may cause side effects.

Do not use potassium supplements or salt substitutes, unless your doctor has told you to.

What are the possible side effects of hydrochlorothiazide and irbesartan?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, this medicine can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Also call your doctor at once if you have:

  • eye pain, vision problems;
  • a light-headed feeling, like you might pass out;
  • little or no urinating;
  • jaundice (yellowing of the skin or eyes);
  • easy bruising, unusual bleeding; or
  • signs of an electrolyte imbalance --increased thirst or urination, confusion, vomiting, constipation, muscle pain or weakness, leg cramps, bone pain, lack of energy, irregular heartbeats, tingly feeling.

Common side effects may include:

  • dizziness;
  • muscle or joint pain; or
  • feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hydrochlorothiazide and irbesartan?

If you also take cholestyramine or colestipol, take your hydrochlorothiazide and irbesartan dose 4 hours before or 4 hours after you take the other medicine.

Tell your doctor about all your other medicines, especially:

  • carbamazepine;
  • insulin or oral diabetes medicine;
  • lithium; or
  • NSAIDs (nonsteroidal anti-inflammatory drugs) --aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may affect hydrochlorothiazide and irbesartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about hydrochlorothiazide and irbesartan.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

© 2019 Cigna. All rights reserved
Language Assistance

Disclaimer

Individual and family medical and dental insurance plans are insured by Cigna Health and Life Insurance Company (CHLIC), Cigna HealthCare of Arizona, Inc., Cigna HealthCare of Georgia, Inc., Cigna HealthCare of Illinois, Inc., and Cigna HealthCare of North Carolina, Inc. Group health insurance and health benefit plans are insured or administered by CHLIC, Connecticut General Life Insurance Company (CGLIC), or their affiliates (see a listing of the legal entities that insure or administer group HMO, dental HMO, and other products or services in your state). Group Universal Life (GUL) insurance plans are insured by CGLIC. Life (other than GUL), accident, critical illness, hospital indemnity, and disability plans are insured or administered by Life Insurance Company of North America, except in NY, where insured plans are offered by Cigna Life Insurance Company of New York (New York, NY). All insurance policies and group benefit plans contain exclusions and limitations. For availability, costs and complete details of coverage, contact a licensed agent or Cigna sales representative. This website is not intended for residents of New Mexico.

 Selecting these links will take you away from Cigna.com to another website, which may be a non-Cigna website. Cigna may not control the content or links of non-Cigna websites. Details