istradefylline

Pronunciation: IS tra DEF i lin

Brand: Nourianz

What is the most important information I should know about istradefylline?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What is istradefylline?

Istradefylline is given with levodopa and carbidopa to treat "wearing-off" episodes (muscle stiffness, loss of muscle control) in people with Parkinson's disease.

Istradefylline may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking istradefylline?

Tell your doctor if you have ever had:

  • abnormal muscle movements;
  • mental illness or psychosis;
  • liver disease; or
  • if you smoke.

Tell your doctor if you are pregnant or breastfeeding.

How should I take istradefylline?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Istradefylline is usually taken once per day. Follow your doctor's dosing instructions very carefully.

You may take istradefylline with or without food.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking istradefylline?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of istradefylline?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • uncontrolled or involuntary muscle movements;
  • unusual thoughts or behavior;
  • confusion, hallucinations; or
  • risk-taking behavior, being impulsive.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.

Common side effects may include:

  • involuntary muscle movements;
  • hallucinations;
  • dizziness;
  • nausea, constipation; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect istradefylline?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect istradefylline, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about istradefylline.

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