Pronunciation: len VA ti nib
Brand: Lenvima
10 mg daily-dose, capsule, red/yellow, imprinted with LOGO, LENV 10 mg
14 mg daily-dose, capsule
20 mg daily-dose, capsule, yellow, imprinted with LOGO, LENV 10 mg
24 mg daily-dose
Some people taking lenvatinib have developed a perforation (a hole or tear) or a fistula (an abnormal passageway) within the stomach or intestines. Get emergency medical help if you have severe stomach pain, or if you feel like you are choking and gagging when you eat or drink.
Call your doctor at once if you have signs of serious side effects, including: severe chest pain, shortness of breath, swelling in your ankles, numbness or weakness, confusion, severe headache, problems with speech or vision, seizure (convulsions), unusual bleeding, coughing up blood, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).
Lenvatinib is used to treat thyroid cancer after radioactive iodine has been tried without success.
Lenvatinib is also used to treat liver cancer that cannot be removed with surgery.
Lenvatinib is used together with everolimus (Afinitor) to treat advanced kidney cancer in people who have received one treatment course with another cancer medicine.
Lenvatinib is used together with pembrolizumab (Keytruda) to treat advanced kidney cancer that has spread to other parts of the body (metastatic), or cannot be removed with surgery.
Lenvatinib is also used with Keytruda to treat a certain type of endometrial cancer (uterine cancer) that has progressed and cannot be removed with surgery or radiation.
Lenvatinib may also be used for purposes not listed in this medication guide.
Tell your doctor if you have ever had:
This medicine may cause jaw bone problems (osteonecrosis). The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation. Ask your doctor about your own risk.
May harm an unborn baby. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 30 days after your last dose.
Pregnancy may be less likely to occur while the mother or the father is using this medicine. Women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.
Do not breastfeed while using this medicine, and for at least 1 week after your last dose.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take lenvatinib at the same time each day, with or without food.
To get a full dose, you may need to take a combination of capsules with different amounts (strengths) of lenvatinib in them. Follow your doctor's dosing instructions very carefully.
Swallow the capsule whole and do not crush, chew, break, or open it.
If you cannot swallow a capsule whole, dissolve the capsules in water as follows:
Call your doctor if you are sick with vomiting or severe diarrhea. Prolonged illness can lead to dehydration and kidney failure.
Drink plenty of liquids if you have diarrhea.
Carefully follow your doctor's instructions about when to start taking medicine to prevent diarrhea while you are using lenvatinib.
You will need frequent medical tests and blood pressure checks.
Pay special attention to your dental hygiene while taking lenvatinib. Brush and floss your teeth regularly.
If you need to have any dental work or surgery, tell the dentist or doctor ahead of time that you are using lenvatinib.
Store at room temperature away from moisture and heat.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some people taking lenvatinib have developed a perforation (a hole or tear) or a fistula (an abnormal passageway) within the stomach or intestines. Call your doctor if you have severe stomach pain, or if you feel like you are choking and gagging when you eat or drink.
Also call your doctor at once if you have:
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Lenvatinib can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.
Tell your doctor about all your other medicines, especially an osteoporosis medicine.
Other drugs may affect lenvatinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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