levoleucovorin

Pronunciation: LEE voe LOO koe voe rin

Brand: Khapzory

What is the most important information I should know about levoleucovorin?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What is levoleucovorin?

Levoleucovorin is used to treat or prevent toxic effects of methotrexate in people who have received methotrexate to treat bone cancer.

Levoleucovorin is also used to treat or prevent toxic effects of methotrexate in people whose bodies do not eliminate methotrexate properly after the drug is metabolized. Levoleucovorin may also be used to treat toxic effects of an overdose or methotrexate or certain other medications.

Levoleucovorin is also used in combination chemotherapy with fluorouracil to treat colorectal cancer that has spread to other parts of the body.

Levoleucovorin should not be used to treat anemia that is caused by a lack of vitamin B12.

Levoleucovorin may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before I receive levoleucovorin?

You should not be treated with this medicine if you are allergic to levoleucovorin, folic acid, or folinic acid.

If possible, before you receive levoleucovorin, tell your doctor or caregivers if you have:

  • kidney disease; or
  • if you are dehydrated.

Tell your doctor if you are pregnant or breastfeeding.

How is levoleucovorin given?

Levoleucovorin is given as an infusion into a vein. A healthcare provider will give you this injection.

For use with methotrexate, levoleucovorin is usually given every 3 to 6 hours.

For colorectal cancer, levoleucovorin is usually given daily as a 5-day treatment, repeated every 4 to 5 weeks.

After treatment with levoleucovorin, you will be watched to make sure this medicine has been effective.

You will need frequent medical tests to help your doctor determine how long to treat you with levoleucovorin.

What happens if I miss a dose?

If this medicine is given by a healthcare professional in an clinical setting, you are not likely to miss a dose.

If you are receiving levoleucovorin daily in 4-week treatment cycles, call your doctor for instructions if you miss an appointment for your scheduled injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving levoleucovorin?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of levoleucovorin?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor or caregivers at once if you have:

  • blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;
  • severe or ongoing diarrhea;
  • a light-headed feeling, like you might pass out;
  • seizure (convulsions);
  • dehydration symptoms --feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin; or
  • kidney problems --little or no urination; painful or difficult urination; swelling in your feet or ankles.

Common side effects may include:

  • diarrhea, nausea, vomiting; or
  • pain or sores in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect levoleucovorin?

Tell your doctor about all your other medicines, especially:

  • seizure medicine --phenobarbital, phenytoin, primidone;
  • a multivitamin or mineral supplement than contains folic acid; or
  • a sulfa drug (Bactrim, Septra, Sulfatrim, SMX-TMP or SMZ-TMP, and others).

This list is not complete. Other drugs may affect levoleucovorin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your doctor or pharmacist can provide more information about levoleucovorin.

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