levomilnacipran

What is the most important information I should know about levomilnacipran?

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

What is levomilnacipran?

Levomilnacipran is a serotonin and norepinephrine reuptake inhibitor antidepressant (SNRI).

Levomilnacipran is used to treat major depressive disorder.

A similar medicine called milnacipran (Savella) is used to treat a chronic pain disorder called fibromyalgia. Levomilnacipran (Fetzima) should not be used to treat fibromyalgia.

Levomilnacipran may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking levomilnacipran?

Do not use levomilnacipran within 7 days before or 14 days after you have taken an MAO inhibitor. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine.

Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with levomilnacipran could cause a serious condition called serotonin syndrome.

Tell your doctor if you have ever had:

• glaucoma;
• heart problems, high blood pressure;
• a stroke;
• bleeding problems;
• urination problems;
• kidney disease;
• a seizure;
• low levels of sodium in your blood;
• bipolar disorder (manic depression);
• if there is a history of depression, manic behavior, or suicide in your family; or
• if you drink alcohol.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking this medicine during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop levomilnacipran without asking your doctor.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of levomilnacipran on the baby.

If you breastfeed while taking levomilnacipran, tell your doctor if your baby is agitated or irritable and has feeding problems or trouble gaining weight.

How should I take levomilnacipran?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take the medicine at the same time each day, with or without food.

Your blood pressure and heart rate will need to be checked often.

You may have withdrawal symptoms if you stop using levomilnacipran suddenly. Ask your doctor before stopping the medicine.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

What should I avoid while taking levomilnacipran?

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen, naproxen, Advil, Aleve, Motrin, and others. Using an NSAID with levomilnacipran may cause you to bruise or bleed easily.

What are the possible side effects of levomilnacipran?

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

• blurred vision, tunnel vision, eye pain or swelling, eye redness;
• painful or difficult urination;
• easy bruising, unusual bleeding, purple or red spots under your skin;
• pounding heartbeats or fluttering in your chest;
• seizure (convulsions);
• manic episodes --racing thoughts, increased energy, decreased need for sleep, risk-taking behavior, being agitated or talkative; or
• low sodium level --headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.

Serious side effects may be more likely in older adults.

Common side effects may include:

• nausea, vomiting, constipation;
• irregular heartbeats;
• sweating; or
• decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect levomilnacipran?

Tell your doctor about all your other medicines, especially:

• any other antidepressant;
• sibutramine;
• St. John's wort;
• tryptophan (sometimes called L-tryptophan);
• a diuretic or "water pill";
• a blood thinner (warfarin, Coumadin, Jantoven);
• diet pills, stimulants, or medicine to treat attention deficit hyperactivity disorder (ADHD) such as Adderall or Ritalin;
• pain medication --fentanyl, tramadol;
• medicine to treat anxiety, mood disorders, thought disorders, or mental illness --buspirone, lithium, and many others; or
• migraine headache medicine --sumatriptan, rizatriptan, zolmitriptan, and others.

This list is not complete. Other drugs may affect levomilnacipran, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about levomilnacipran.