Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.
Lopinavir and ritonavir can cause a serious heart problem. Call your doctor at once if you have fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out).
Tell your doctor if you have signs of liver or pancreas problems: loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Lopinavir and ritonavir is a combination antiviral medicine used to treat human immunodeficiency virus (HIV), the virus that can cause acquired immunodeficiency syndrome (AIDS). This medicine is not a cure for HIV or AIDS.
Lopinavir and ritonavir is for use in adults and children who are at least 14 days old.
Lopinavir and ritonavir may also be used for purposes not listed in this medication guide.
You should not use this medicine if you have ever had a severe allergic reaction to lopinavir or ritonavir.
Some medicines can cause unwanted or dangerous effects when used with lopinavir and ritonavir. Your doctor may change your treatment plan if you also use:
Tell your doctor if you have ever had:
Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.
Lopinavir and ritonavir oral solution (liquid) contains alcohol and propylene glycol. Do not use the liquid form of this medicine if you become pregnant.
Lopinavir and ritonavir can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. To prevent pregnancy while using lopinavir and ritonavir, use a barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge.
Women with HIV or AIDS should not breastfeed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed, especially when giving the medicine to a child
Swallow the tablet whole and do not crush, chew, or break it.
The tablets can be taken with or without food.
Lopinavir and ritonavir liquid should be taken with food. Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
Ask your doctor before giving lopinavir and ritonavir liquid through a feeding tube.
Lopinavir and ritonavir doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight.
You will need frequent medical tests.
Use all HIV medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Every person with HIV should remain under the care of a doctor.
Store lopinavir and ritonavir liquid in the refrigerator or at room temperature.
Store the tablets at room temperature, away from heat and moisture. Keep the pills in their original container. If you store the liquid at room temperature you must use it within 60 days.
Lopinavir and ritonavir liquid contains alcohol and propylene glycol. Avoid drinking alcohol while using this medicine.
Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Call your doctor at once if you have:
Lopinavir and ritonavir affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:
Lopinavir and ritonavir liquid contains alcohol and propylene glycol, which may cause drowsiness or slow breathing in a baby taking this medicine. Tell your doctor if you notice these symptoms in your baby.
Lopinavir and ritonavir can cause changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Lopinavir and ritonavir can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.
Some medicines can make lopinavir and ritonavir less effective when taken at the same time. If you take lopinavir and ritonavir liquid and you also take didanosine (Videx), take the didanosine at least 1 hour before or 2 hours after you take lopinavir and ritonavir liquid.
Many drugs can affect lopinavir and ritonavir, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2021 Cerner Multum, Inc. Version: 13.01. Revision date: 3/31/2021.
Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.