Pronunciation: loo bee PROS tone

Brand: Amitiza


slide 1 of 2, Amitiza,

8 mcg, oval, pink, imprinted with SPI

Image of Amitiza
slide 1 of 2


slide 2 of 2, Amitiza,

24 mcg, oval, orange, imprinted with SPI

Image of Amitiza
slide 2 of 2

What is the most important information I should know about lubiprostone?

You should not use this medicine if you have a blockage in your digestive tract, or if you have severe diarrhea.

Stop taking lubiprostone and call your doctor if you feel light-headed every time you take this medicine.

What is lubiprostone?

Lubiprostone is used to treat chronic constipation, or constipation caused by opioid (narcotic) pain medicine.

Lubiprostone may also be used to treat irritable bowel syndrome in women with constipation as the main symptom.

Lubiprostone is for use in adults.

Lubiprostone may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking lubiprostone?

You should not use lubiprostone if you have a blockage in your digestive tract, or if you have severe diarrhea.

Tell your doctor if you have ever had liver disease.

Tell your doctor if you are pregnant or breastfeeding.

A nursing baby could develop diarrhea if the mother takes lubiprostone while breastfeeding. Ask your doctor about any risk, and tell your doctor if the baby develops diarrhea.

How should I take lubiprostone?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take lubiprostone with food and water to prevent nausea.

Swallow the capsule whole and do not crush, chew, break, or open it.

You may have tightness in your chest or feel short of breath within 1 hour after taking lubiprostone. This side effect should go away within 3 hours, but it may occur again when you take your next dose. Talk with your doctor if this side effect becomes bothersome.

Do not take lubiprostone if you have severe diarrhea. Call your doctor for instructions.

Your doctor will need to check your progress on a regular basis.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking lubiprostone?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of lubiprostone?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • trouble breathing;
  • severe or ongoing nausea or diarrhea; or
  • a light-headed feeling, like you might pass out.

You may have low blood pressure and feel faint shortly after taking lubiprostone, especially if you've been sick with vomiting or diarrhea. Stop taking lubiprostone and call your doctor if you feel light-headed after every dose.

Common side effects may include:

  • nausea, stomach pain;
  • diarrhea, gas, bloating; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect lubiprostone?

Make sure your doctor knows if you are using opioid pain medicine.

Other drugs may affect lubiprostone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about lubiprostone.

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