Pronunciation: met FOR min and PYE o GLI ta zone
Brand: Actoplus Met, Actoplus Met XR
500 mg-15 mg, oval, white, imprinted with TV, 7677
850 mg-15 mg, oval, white, imprinted with TV, 7678
500 mg-15 mg, oval, white, imprinted with MYLAN, P155
850 mg-15 mg, oval, white, imprinted with MYLAN, P157
500 mg-15 mg, oval, white, imprinted with SZ441
850 mg-15 mg, oval, white, imprinted with SZ442
500 mg-15 mg, capsule, white, imprinted with 15 500, 1280
500 mg-15 mg, oval, white, imprinted with 4833M, 15/500
850 mg-15 mg, oval, white, imprinted with 4833M, 15/850
1000 mg-30 mg, round, white, imprinted with 4833X 30/1000
1000 mg-15 mg, round, white, imprinted with 4833x 15/1000
500 mg-15 mg, oval, white, imprinted with 4833M, 15/500
850 mg-15 mg, oval, white, imprinted with 4833M, 15/850
You should not use this medicine if you have severe heart failure, severe kidney disease, active bladder cancer, metabolic acidosis, or ketoacidosis (call your doctor for treatment).
Metformin and pioglitazone can cause or worsen congestive heart failure. Call your doctor at once if you have shortness of breath (even with mild exertion), swelling, or rapid weight gain.
If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking metformin and pioglitazone.
You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.
Metformin and pioglitazone is a combination of two oral diabetes medicines that help control blood sugar levels.
Metformin and pioglitazone is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus who do not use daily insulin injections. Metformin and pioglitazone is not for treating type 1 diabetes.
Metformin and pioglitazone may also be used for purposes not listed in this medication guide.
You should not use this medicine if you are allergic to metformin or pioglitazone, or if you have:
If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking metformin and pioglitazone. Be sure your caregivers know ahead of time that you are using this medicine.
Tell your doctor if you have ever had:
This medication may increase your risk of developing bladder cancer. Talk with your doctor about your specific risk.
You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.
Metformin and pioglitazone may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.
Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.
Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.
Women may be more likely to have a broken bone while using metformin and pioglitazone. Talk with your doctor about ways to keep your bones healthy.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
Metformin and pioglitazone is not approved for use by anyone younger than 18 years old.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take metformin and pioglitazone with meals. Take the extended-release tablet once daily with your evening meal.
Swallow the tablet whole and do not crush, chew, or break it.
You may have low blood sugar (hypoglycemia) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda).
Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency.
Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.
Metformin and pioglitazone is only part of a complete treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.
If you take extra vitamin B12 while you are taking metformin and pioglitazone, take only the amount of vitamin B12 that your doctor has prescribed.
Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some people using metformin and pioglitazone develop lactic acidosis, which can be fatal. Get emergency medical help if you have even mild symptoms such as:
Call your doctor at once if you have:
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Many drugs can affect metformin and pioglitazone, making this medicine less effective or increasing your risk of lactic acidosis. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2022 Cerner Multum, Inc. Version: 14.02. Revision date: 4/9/2020.
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