How should I use metreleptin?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Metreleptin is injected under the skin. A healthcare provider will teach you how to properly use the medication by yourself. Metreleptin should not be injected into a muscle or vein.
Metreleptin is usually given once daily at any time of day, with or without food.
Metreleptin doses are based on weight (especially in children and teenagers). Your dose needs may change if you gain or lose weight.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.
Metreleptin must be mixed with a liquid (diluent) before using it. When using injections by yourself, be sure you understand how to properly mix and store the medicine. Do not mix metreleptin with other medicines in the same vial or syringe.
Prepare an injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.
When preparing a metreleptin dose for an infant: Do not use a diluent called Bacteriostatic Water for Injection (BWFI). BWFI contains an ingredient that can cause serious side effects or death in very young infants or premature babies. Use only Sterile Water for Injection (WFI) or the diluent that your doctor or pharmacist has recommended.
Store unmixed metreleptin vials in their original container in the refrigerator. Protect from light. Do not freeze. Do not use the medicine if the powder in the vial has changed colors, or if the expiration date on the label has passed.
Metreleptin mixed with BWFI must be used within 3 days. Store the mixture in the refrigerator.
Metreleptin mixed with WFI must be used right away. WFI contains no preservative. Do not save for later use.
Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.
Low blood sugar (hypoglycemia) can occur during treatment with metreleptin, especially if you also use insulin or oral diabetes medicine. Ask your doctor how to best treat low blood sugar. If you are diabetic, check your blood sugar carefully while using metreleptin.