You should not use this medicine if you have heart problems, uncontrolled high blood pressure, blood circulation problems, Wolff-Parkinson-White Syndrome, a history of heart attack or stroke, severe liver disease, a history of severe allergic reaction to aspirin or an NSAID, or if you are in late pregnancy.
Naproxen can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Naproxen may also cause stomach or intestinal bleeding, which can be fatal.
Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.
Do not take naproxen and sumatriptan within 24 hours before or after using another migraine headache medicine.
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Sumatriptan is a migraine headache medicine.
Naproxen and sumatriptan is a combination medicine used to treat migraine headaches. This medicine will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.
Naproxen and sumatriptan should not be used to treat cluster headaches or any headache that causes loss of movement on one side of your body.
Naproxen and sumatriptan may also be used for purposes not listed in this medication guide.
You should not use this medicine if you are allergic to naproxen (Aleve, Anaprox, Naprosyn) or sumatriptan (Imitrex), or if you have:
Naproxen can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Naproxen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using naproxen and sumatriptan, especially in older adults.
Do not use naproxen and sumatriptan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Do not take naproxen and sumatriptan within 24 hours before or after using another migraine headache medicine, including:
Tell your doctor if you have ever had:
If you are pregnant, you should not take naproxen unless your doctor tells you to. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.
You should not breastfeed while you are taking this medicine.
Naproxen and sumatriptan is not approved for use by anyone younger than 12 years old.
Follow all directions on your prescription label and read all medication guides. Use the lowest dose that is effective in treating your condition. Overuse of migraine headache medicine can actually make your headaches worse.
Take 1 tablet as soon as you notice headache symptoms, or after an attack has already begun. You may take the medicine with or without food.
Swallow the tablet whole and do not crush, chew, or break it.
If your headache does not go away, call your doctor before taking a second tablet. If your headache does not completely go away, or goes away and comes back, take a second tablet 2 hours after the first.
If you are 12 to 17 years old: Do not take a second tablet without first asking your doctor.
You must wait at least 2 hours before you take a second tablet. Do not take more than 2 tablets in 24 hours. If your symptoms have not improved, call your doctor before taking any more tablets.
You should not use this medicine to treat more than 5 headaches in 30 days (or more than 2 headaches in 30 days if you are 12 to 17 years old).
Store at room temperature away from moisture and heat.
Avoid drinking alcohol. It may increase your risk of stomach bleeding.
Avoid taking aspirin or other salicylates such as Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others.
Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.
Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to naproxen (such as aspirin, ibuprofen, or ketoprofen).
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Stop taking this medicine and seek emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.
Stop using this medicine and call your doctor at once if you have:
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Ask your doctor before using naproxen and sumatriptan if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily.
Tell your doctor about all your other medicines, especially:
This list is not complete. Other drugs may affect naproxen and sumatriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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